| pubmed-article:14522944 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14522944 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:14522944 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:14522944 | lifeskim:mentions | umls-concept:C1136031 | lld:lifeskim |
| pubmed-article:14522944 | lifeskim:mentions | umls-concept:C1820192 | lld:lifeskim |
| pubmed-article:14522944 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:14522944 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:14522944 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:14522944 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:14522944 | pubmed:dateCreated | 2003-10-2 | lld:pubmed |
| pubmed-article:14522944 | pubmed:abstractText | Cytokines, such as tumor necrosis factor-alpha (TNFalpha), potently inhibit the differentiation of mesenchymal cells and down-regulate the expression of Sox9 and MyoD, transcription factors required for chondrocyte and myocyte development. Previously, we demonstrated that NF-kappaB controls TNFalpha-mediated suppression of myogenesis through a mechanism involving MyoD mRNA down-regulation. Here, we show that NF-kappaB also suppresses chondrogenesis and destabilizes Sox9 mRNA levels. Multiple copies of an mRNA cis-regulatory motif (5'-ACUACAG-3') are necessary and sufficient for NF-kappaB-mediated Sox9 and MyoD down-regulation. Thus, in response to cytokine signaling, NF-kappaB modulates the differentiation of mesenchymal-derived cell lineages via RNA sequence-dependent, posttranscriptional down-regulation of key developmental regulators. | lld:pubmed |
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| pubmed-article:14522944 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14522944 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14522944 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14522944 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14522944 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:14522944 | pubmed:author | pubmed-author:BaldwinAlbert... | lld:pubmed |
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| pubmed-article:14522944 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:14522944 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:14522944 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14522944 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14522944 | pubmed:pagination | 2368-73 | lld:pubmed |
| pubmed-article:14522944 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:14522944 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14522944 | pubmed:articleTitle | NF-kappaB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism. | lld:pubmed |
| pubmed-article:14522944 | pubmed:affiliation | Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. | lld:pubmed |
| pubmed-article:14522944 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14522944 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14522944 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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