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pubmed-article:14520423pubmed:issue8lld:pubmed
pubmed-article:14520423pubmed:dateCreated2003-10-1lld:pubmed
pubmed-article:14520423pubmed:abstractTextAllogeneic stem cell transplantation (allo-SCT) is an effective and potentially curative treatment for some cases of multiple myeloma (MM). The curative efficacy of allo-SCT may be largely attributed to its immunological activity, the graft-versus-myeloma (GVM) effect. To evaluate the kinetics of residual myeloma cells, we analyzed the follow-up bone marrow samples of three MM patients by means of a real-time molecular assay. We identified a consistent correlation between onset of graft-versus-host disease and disease response. These data suggest that real-time molecular follow-up can be used to monitor the GVM effect and that it can be employed in the clinical setting to tailor post transplant immunomodulation.lld:pubmed
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pubmed-article:14520423pubmed:volume32lld:pubmed
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pubmed-article:14520423pubmed:pagination791-3lld:pubmed
pubmed-article:14520423pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:14520423pubmed:year2003lld:pubmed
pubmed-article:14520423pubmed:articleTitleDetection of minimal residual disease by real-time PCR can be used as a surrogate marker to evaluate the graft-versus-myeloma effect after allogeneic stem cell transplantation.lld:pubmed
pubmed-article:14520423pubmed:affiliationLaboratorio Ematologia Molecolare, Istituto Scientifico HS Raffaele, Milano, Italy.lld:pubmed
pubmed-article:14520423pubmed:publicationTypeJournal Articlelld:pubmed