| pubmed-article:14505570 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14505570 | lifeskim:mentions | umls-concept:C1882071 | lld:lifeskim |
| pubmed-article:14505570 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:14505570 | lifeskim:mentions | umls-concept:C1512301 | lld:lifeskim |
| pubmed-article:14505570 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:14505570 | pubmed:dateCreated | 2003-9-24 | lld:pubmed |
| pubmed-article:14505570 | pubmed:abstractText | HIV release requires TSG101, a cellular factor that sorts proteins into vesicles that bud into multivesicular bodies (MVB). To test whether other proteins involved in MVB biogenesis (the class E proteins) also participate in HIV release, we identified 22 candidate human class E proteins. These proteins were connected into a coherent network by 43 different protein-protein interactions, with AIP1 playing a key role in linking complexes that act early (TSG101/ESCRT-I) and late (CHMP4/ESCRT-III) in the pathway. AIP1 also binds the HIV-1 p6(Gag) and EIAV p9(Gag) proteins, indicating that it can function directly in virus budding. Human class E proteins were found in HIV-1 particles, and dominant-negative mutants of late-acting human class E proteins arrested HIV-1 budding through plasmal and endosomal membranes. These studies define a protein network required for human MVB biogenesis and indicate that the entire network participates in the release of HIV and probably many other viruses. | lld:pubmed |
| pubmed-article:14505570 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14505570 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14505570 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:14505570 | pubmed:issn | 0092-8674 | lld:pubmed |
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| pubmed-article:14505570 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14505570 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:14505570 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:14505570 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14505570 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14505570 | pubmed:pagination | 701-13 | lld:pubmed |
| pubmed-article:14505570 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:14505570 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14505570 | pubmed:articleTitle | The protein network of HIV budding. | lld:pubmed |
| pubmed-article:14505570 | pubmed:affiliation | Department of Biochemistry, University of Utah, Salt Lake City, UT 84132, USA. | lld:pubmed |
| pubmed-article:14505570 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14505570 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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