| pubmed-article:1448774 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1448774 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:1448774 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:1448774 | lifeskim:mentions | umls-concept:C0003440 | lld:lifeskim |
| pubmed-article:1448774 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:1448774 | lifeskim:mentions | umls-concept:C0087086 | lld:lifeskim |
| pubmed-article:1448774 | lifeskim:mentions | umls-concept:C1708528 | lld:lifeskim |
| pubmed-article:1448774 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1448774 | pubmed:dateCreated | 1992-12-30 | lld:pubmed |
| pubmed-article:1448774 | pubmed:abstractText | We compared the abilities of heparin and two direct thrombin inhibitors to prevent fibrin accretion onto pre-existing thrombi in rabbits. Inhibition of thrombus growth was measured as the ability of each test compound to inhibit the accretion of 125I-fibrin onto thrombi pre-formed in jugular veins of rabbits. When administered as a continuous infusion, the two direct (i.e. antithrombin III-independent) thrombin inhibitors, r-hirudin and a tripeptide, Ac(D)-Phe-Pro-bor-Arg (P-8714) inhibited fibrin accretion as effectively as heparin, but did so in doses which generated little systemic anticoagulation, as compared to the marked anticoagulation associated with the heparin effect. However, both r-hirudin and P-8714 were more effective when they were administered as a single bolus injection than as a continuous infusion. Under the former conditions, there was only a transient systemic anticoagulant effect. We conclude that direct or antithrombin III-independent thrombin inhibitors are more effective than heparin in preventing thrombus growth. The limited effect of heparin is likely due to fibrin impairing the ability of heparin/antithrombin III to inactivate thrombin. | lld:pubmed |
| pubmed-article:1448774 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1448774 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1448774 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1448774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1448774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1448774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1448774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1448774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1448774 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1448774 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1448774 | pubmed:issn | 0340-6245 | lld:pubmed |
| pubmed-article:1448774 | pubmed:author | pubmed-author:BuchananM RMR | lld:pubmed |
| pubmed-article:1448774 | pubmed:author | pubmed-author:CauPP | lld:pubmed |
| pubmed-article:1448774 | pubmed:author | pubmed-author:OfosuF AFA | lld:pubmed |
| pubmed-article:1448774 | pubmed:author | pubmed-author:Brill-Edwards... | lld:pubmed |
| pubmed-article:1448774 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:1448774 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1448774 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:1448774 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:1448774 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1448774 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1448774 | pubmed:pagination | 424-7 | lld:pubmed |
| pubmed-article:1448774 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1448774 | pubmed:meshHeading | pubmed-meshheading:1448774-... | lld:pubmed |
| pubmed-article:1448774 | pubmed:meshHeading | pubmed-meshheading:1448774-... | lld:pubmed |
| pubmed-article:1448774 | pubmed:meshHeading | pubmed-meshheading:1448774-... | lld:pubmed |
| pubmed-article:1448774 | pubmed:meshHeading | pubmed-meshheading:1448774-... | lld:pubmed |
| pubmed-article:1448774 | pubmed:meshHeading | pubmed-meshheading:1448774-... | lld:pubmed |
| pubmed-article:1448774 | pubmed:meshHeading | pubmed-meshheading:1448774-... | lld:pubmed |
| pubmed-article:1448774 | pubmed:meshHeading | pubmed-meshheading:1448774-... | lld:pubmed |
| pubmed-article:1448774 | pubmed:meshHeading | pubmed-meshheading:1448774-... | lld:pubmed |
| pubmed-article:1448774 | pubmed:meshHeading | pubmed-meshheading:1448774-... | lld:pubmed |
| pubmed-article:1448774 | pubmed:meshHeading | pubmed-meshheading:1448774-... | lld:pubmed |
| pubmed-article:1448774 | pubmed:meshHeading | pubmed-meshheading:1448774-... | lld:pubmed |
| pubmed-article:1448774 | pubmed:meshHeading | pubmed-meshheading:1448774-... | lld:pubmed |
| pubmed-article:1448774 | pubmed:meshHeading | pubmed-meshheading:1448774-... | lld:pubmed |
| pubmed-article:1448774 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1448774 | pubmed:articleTitle | Prevention of thrombus growth by antithrombin III-dependent and two direct thrombin inhibitors in rabbits: implications for antithrombotic therapy. | lld:pubmed |
| pubmed-article:1448774 | pubmed:affiliation | Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada. | lld:pubmed |
| pubmed-article:1448774 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1448774 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1448774 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
