| pubmed-article:1433572 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1433572 | lifeskim:mentions | umls-concept:C0005684 | lld:lifeskim |
| pubmed-article:1433572 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:1433572 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:1433572 | lifeskim:mentions | umls-concept:C0007578 | lld:lifeskim |
| pubmed-article:1433572 | lifeskim:mentions | umls-concept:C0333516 | lld:lifeskim |
| pubmed-article:1433572 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1433572 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:1433572 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1433572 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1433572 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1433572 | pubmed:dateCreated | 1992-11-27 | lld:pubmed |
| pubmed-article:1433572 | pubmed:abstractText | The constitutive expression by eight human bladder cancer cell lines of the cell adhesion molecules intercellular adhesion molecule-1 and intercellular adhesion molecule-2 was studied using monoclonal antibody probes in conjunction with flow-cytometry. Tumour lines of low grade (G1) did not constitutively express intercellular adhesion molecule-1, rather they were found to express intercellular adhesion molecule-2. The G2 cells expressed no intercellular adhesion molecule-2, however, a low percentage did express intercellular adhesion molecule-1. High grade cells (G3) only expressed intercellular adhesion molecule-1 on their cell surface but at higher levels than the G2 cell line. Exposure of the bladder cancer cell lines to interferon-gamma induced and augmented the expression of intercellular adhesion molecule-1 by all except one of the cell lines (UMUC3). Intercellular adhesion molecule-2 expression remained unaltered. The modulation of intercellular adhesion molecule-1 expression was dependent on the concentration of interferon-gamma and the duration of stimulus. De novo intercellular adhesion molecule-1 expression, induced by interferon-gamma, was rapid (< 4 hours) with only a short period of stimulation being required (< 10 seconds). The rapid increase in expression of intercellular adhesion molecule-1 required de novo protein synthesis and was not the result of release of intercellular adhesion molecule-1 from an intracellular pool. Interferon-gamma and tumour necrosis factor-alpha were found to act synergistically in the induction and augmentation of intercellular adhesion molecule-1 expression. Optimal induction occurred with 10 Uml-1 of both molecules. These results suggest a correlation between constitutive adhesion molecule expression and the histopathological grade of the tumour. The implications of these findings for Bacillus Calmette Guerin and interferon-gamma immunotherapy of bladder cancer is discussed. | lld:pubmed |
| pubmed-article:1433572 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1433572 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1433572 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1433572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1433572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1433572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1433572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1433572 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1433572 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1433572 | pubmed:issn | 0022-5347 | lld:pubmed |
| pubmed-article:1433572 | pubmed:author | pubmed-author:JamesKK | lld:pubmed |
| pubmed-article:1433572 | pubmed:author | pubmed-author:ChisholmG DGD | lld:pubmed |
| pubmed-article:1433572 | pubmed:author | pubmed-author:JacksonA MAM | lld:pubmed |
| pubmed-article:1433572 | pubmed:author | pubmed-author:PrescottSS | lld:pubmed |
| pubmed-article:1433572 | pubmed:author | pubmed-author:AlexandrovA... | lld:pubmed |
| pubmed-article:1433572 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1433572 | pubmed:volume | 148 | lld:pubmed |
| pubmed-article:1433572 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1433572 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1433572 | pubmed:pagination | 1583-6 | lld:pubmed |
| pubmed-article:1433572 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:1433572 | pubmed:meshHeading | pubmed-meshheading:1433572-... | lld:pubmed |
| pubmed-article:1433572 | pubmed:meshHeading | pubmed-meshheading:1433572-... | lld:pubmed |
| pubmed-article:1433572 | pubmed:meshHeading | pubmed-meshheading:1433572-... | lld:pubmed |
| pubmed-article:1433572 | pubmed:meshHeading | pubmed-meshheading:1433572-... | lld:pubmed |
| pubmed-article:1433572 | pubmed:meshHeading | pubmed-meshheading:1433572-... | lld:pubmed |
| pubmed-article:1433572 | pubmed:meshHeading | pubmed-meshheading:1433572-... | lld:pubmed |
| pubmed-article:1433572 | pubmed:meshHeading | pubmed-meshheading:1433572-... | lld:pubmed |
| pubmed-article:1433572 | pubmed:meshHeading | pubmed-meshheading:1433572-... | lld:pubmed |
| pubmed-article:1433572 | pubmed:meshHeading | pubmed-meshheading:1433572-... | lld:pubmed |
| pubmed-article:1433572 | pubmed:meshHeading | pubmed-meshheading:1433572-... | lld:pubmed |
| pubmed-article:1433572 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1433572 | pubmed:articleTitle | Expression of adhesion molecules by bladder cancer cells: modulation by interferon-gamma and tumour necrosis factor-alpha. | lld:pubmed |
| pubmed-article:1433572 | pubmed:affiliation | Department of Surgery/Urology, University of Edinburgh Medical School, United Kingdom. | lld:pubmed |
| pubmed-article:1433572 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1433572 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1433572 | lld:pubmed |
