| pubmed-article:1431685 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1431685 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:1431685 | lifeskim:mentions | umls-concept:C1522496 | lld:lifeskim |
| pubmed-article:1431685 | lifeskim:mentions | umls-concept:C0234421 | lld:lifeskim |
| pubmed-article:1431685 | lifeskim:mentions | umls-concept:C0032408 | lld:lifeskim |
| pubmed-article:1431685 | lifeskim:mentions | umls-concept:C0034304 | lld:lifeskim |
| pubmed-article:1431685 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:1431685 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:1431685 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:1431685 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1431685 | pubmed:dateCreated | 1992-12-18 | lld:pubmed |
| pubmed-article:1431685 | pubmed:abstractText | The pyrogenic interferon inducer polyinosinic:polycytidylic acid (Poly I:C) was shown to activate the rabbit hypothalamo-pituitary-adrenocortical (HPA) axis in vivo. The immunoreactive cortisol response to Poly I:C (2.5 micrograms/kg) was shown to have a corticotrophin-releasing factor-41 (CRF-41)-dependent component which was abolished by peripheral immunoneutralization using an anti-CRF-41 monoclonal antibody (KCHMB001; 2.5 mg/kg i.v.). Peripheral administration of the arginine vasopressin (AVP) V1 receptor antagonist ([deamino-Pen1, O-Me-Tyr2, Arg8]-vasopressin; 225 nmol/kg i.v.) had no effect on the response of immunoreactive cortisol to Poly I:C, suggesting that AVP was not involved in activation of the HPA axis. Poly I:C increased both body temperature and circulating immunoreactive prostaglandin E2; these responses were abolished by the cyclo-oxygenase inhibitor ketoprofen (3 mg/kg s.c.). The immunoreactive cortisol response to Poly I:C, however, remained after the administration of ketoprofen, indicating a prostaglandin (PG)-independent component. The immunoreactive cortisol levels in control, saline vehicle-treated, animals were reduced by both the CRF-41 receptor antagonist (alpha-helical CRF (9-41); 6.25 nmol/kg i.v.) and ketoprofen (3 mg/kg s.c.) indicating that this basal state is dependent on both CRF-41 and PGs. | lld:pubmed |
| pubmed-article:1431685 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1431685 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1431685 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1431685 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1431685 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1431685 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1431685 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1431685 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1431685 | pubmed:issn | 0022-0795 | lld:pubmed |
| pubmed-article:1431685 | pubmed:author | pubmed-author:HillhouseE... | lld:pubmed |
| pubmed-article:1431685 | pubmed:author | pubmed-author:MiltonA SAS | lld:pubmed |
| pubmed-article:1431685 | pubmed:author | pubmed-author:MilloyF JFJ | lld:pubmed |
| pubmed-article:1431685 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1431685 | pubmed:volume | 135 | lld:pubmed |
| pubmed-article:1431685 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1431685 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1431685 | pubmed:pagination | 69-75 | lld:pubmed |
| pubmed-article:1431685 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1431685 | pubmed:meshHeading | pubmed-meshheading:1431685-... | lld:pubmed |
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| pubmed-article:1431685 | pubmed:meshHeading | pubmed-meshheading:1431685-... | lld:pubmed |
| pubmed-article:1431685 | pubmed:meshHeading | pubmed-meshheading:1431685-... | lld:pubmed |
| pubmed-article:1431685 | pubmed:meshHeading | pubmed-meshheading:1431685-... | lld:pubmed |
| pubmed-article:1431685 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1431685 | pubmed:articleTitle | Activation of the hypothalamo-pituitary-adrenocortical axis in the conscious rabbit by the pyrogen polyinosinic:polycytidylic acid is dependent on corticotrophin-releasing factor-41. | lld:pubmed |
| pubmed-article:1431685 | pubmed:affiliation | Department of Clinical Biochemistry, University of Newcastle upon Tyne, U.K. | lld:pubmed |
| pubmed-article:1431685 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1431685 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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