| pubmed-article:1431103 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1431103 | lifeskim:mentions | umls-concept:C0534519 | lld:lifeskim |
| pubmed-article:1431103 | lifeskim:mentions | umls-concept:C0006556 | lld:lifeskim |
| pubmed-article:1431103 | lifeskim:mentions | umls-concept:C0009017 | lld:lifeskim |
| pubmed-article:1431103 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:1431103 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:1431103 | pubmed:dateCreated | 1992-12-8 | lld:pubmed |
| pubmed-article:1431103 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1431103 | pubmed:abstractText | IL-1 beta is a potent modulator of immune and inflammatory responses. Murine IL-1 beta is initially synthesized as an inactive 33-kDa pro-molecule that is activated by proteolytic cleavage between Asp-117 and Val-118 to generate the 17-kDa mature IL-1 beta protein. This cleavage is catalyzed by a specific protease that has been designated the IL-1 beta converting enzyme (or IL-1 beta convertase). We have used a human IL-1 beta convertase cDNA to isolate murine convertase cDNA from a WEHI-3 library. These cDNA predicted that the murine convertase is a 402-residue protein. Overall, the murine convertase showed 71% nucleotide and 62% predicted amino acid sequence identity with the human convertase. Southern blot analysis of interspecific backcross mice indicated that the murine IL-1 beta convertase is encoded by a single copy gene located on murine chromosome 9. The murine convertase showed broad constitutive expression, being detected in mononuclear phagocyte and T lymphocyte cell lines as well as in spleen, heart, brain, and adrenal glands. The expression of the murine convertase in mononuclear phagocytes was up-regulated by treatment with LPS or rIFN-gamma. These studies establish that the IL-1 beta convertase is an evolutionarily conserved, widely expressed enzyme that can be regulated at a pretranslational level. | lld:pubmed |
| pubmed-article:1431103 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1431103 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1431103 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1431103 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1431103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1431103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1431103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1431103 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1431103 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1431103 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1431103 | pubmed:author | pubmed-author:CopelandN GNG | lld:pubmed |
| pubmed-article:1431103 | pubmed:author | pubmed-author:ChaplinD DDD | lld:pubmed |
| pubmed-article:1431103 | pubmed:author | pubmed-author:GilbertD JDJ | lld:pubmed |
| pubmed-article:1431103 | pubmed:author | pubmed-author:JenkinsN ANA | lld:pubmed |
| pubmed-article:1431103 | pubmed:author | pubmed-author:CerrettiD PDP | lld:pubmed |
| pubmed-article:1431103 | pubmed:author | pubmed-author:BlackR ARA | lld:pubmed |
| pubmed-article:1431103 | pubmed:author | pubmed-author:BernalR MRM | lld:pubmed |
| pubmed-article:1431103 | pubmed:author | pubmed-author:NettM AMA | lld:pubmed |
| pubmed-article:1431103 | pubmed:author | pubmed-author:SeavittJJ | lld:pubmed |
| pubmed-article:1431103 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1431103 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1431103 | pubmed:volume | 149 | lld:pubmed |
| pubmed-article:1431103 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1431103 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1431103 | pubmed:pagination | 3254-9 | lld:pubmed |
| pubmed-article:1431103 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:1431103 | pubmed:meshHeading | pubmed-meshheading:1431103-... | lld:pubmed |
| pubmed-article:1431103 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1431103 | pubmed:articleTitle | Molecular cloning of the murine IL-1 beta converting enzyme cDNA. | lld:pubmed |
| pubmed-article:1431103 | pubmed:affiliation | Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110. | lld:pubmed |
| pubmed-article:1431103 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1431103 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1431103 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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