pubmed-article:1429847 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:1429847 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:1429847 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
pubmed-article:1429847 | lifeskim:mentions | umls-concept:C0041455 | lld:lifeskim |
pubmed-article:1429847 | lifeskim:mentions | umls-concept:C0029463 | lld:lifeskim |
pubmed-article:1429847 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
pubmed-article:1429847 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
pubmed-article:1429847 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
pubmed-article:1429847 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:1429847 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:1429847 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:1429847 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:1429847 | pubmed:dateCreated | 1992-12-1 | lld:pubmed |
pubmed-article:1429847 | pubmed:abstractText | Using MG-63 cells as a model system capable of partial osteoblastic differentiation, we have examined the effect of growth on extracellular matrix. MG-63 cell matrix and purified type I collagen induced a morphological change characterized by long cytoplasmic processes reminiscent of those seen in osteocytes. Concurrent biochemical changes involving bone marker proteins included increased specific activity of cell-associated alkaline phosphatase and increased secretion of osteonectin (up to 2.5-fold for each protein); all changes occurred without alterations in the growth kinetics of the MG-63 cells. The increase in alkaline phosphatase activity was maximal on days 6-8 following seeding; increased osteonectin secretion was most prominent immediately following seeding; all changes decreased as cells reached confluence. Growing cells on type I collagen resulted in an increased induction of alkaline phosphatase activity by 1,25(OH)2D3 (with little change in the 1,25(OH)2D3 induction of osteonectin and osteocalcin secretion), and increased TGF-beta induction of alkaline phosphatase activity as well (both TGF-beta 1 and TGF-beta 2). Both the 1,25(OH)2D3 and TGF-beta effects appeared to be synergistic with growth on type I collagen. These studies support the hypothesis that bone extracellular matrix may play an important role in osteoblastic differentiation and phenotypic expression. | lld:pubmed |
pubmed-article:1429847 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1429847 | pubmed:language | eng | lld:pubmed |
pubmed-article:1429847 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1429847 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:1429847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1429847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1429847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:1429847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1429847 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:1429847 | pubmed:month | Nov | lld:pubmed |
pubmed-article:1429847 | pubmed:issn | 0021-9541 | lld:pubmed |
pubmed-article:1429847 | pubmed:author | pubmed-author:MannK GKG | lld:pubmed |
pubmed-article:1429847 | pubmed:author | pubmed-author:RobinsonJ AJA | lld:pubmed |
pubmed-article:1429847 | pubmed:author | pubmed-author:TracyR PRP | lld:pubmed |
pubmed-article:1429847 | pubmed:author | pubmed-author:AndrianarivoA... | lld:pubmed |
pubmed-article:1429847 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:1429847 | pubmed:volume | 153 | lld:pubmed |
pubmed-article:1429847 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:1429847 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:1429847 | pubmed:pagination | 256-65 | lld:pubmed |
pubmed-article:1429847 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:1429847 | pubmed:year | 1992 | lld:pubmed |
pubmed-article:1429847 | pubmed:articleTitle | Growth on type I collagen promotes expression of the osteoblastic phenotype in human osteosarcoma MG-63 cells. | lld:pubmed |
pubmed-article:1429847 | pubmed:affiliation | Department of Biochemistry, University of Vermont, Burlington 05405. | lld:pubmed |
pubmed-article:1429847 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:1429847 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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