| pubmed-article:1404976 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1404976 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:1404976 | lifeskim:mentions | umls-concept:C0030559 | lld:lifeskim |
| pubmed-article:1404976 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:1404976 | lifeskim:mentions | umls-concept:C0001962 | lld:lifeskim |
| pubmed-article:1404976 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:1404976 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:1404976 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:1404976 | lifeskim:mentions | umls-concept:C1160577 | lld:lifeskim |
| pubmed-article:1404976 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
| pubmed-article:1404976 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:1404976 | pubmed:dateCreated | 1992-11-3 | lld:pubmed |
| pubmed-article:1404976 | pubmed:abstractText | Treatment of isolated parietal cells from guinea pig gastric mucosa with ethanol caused a rapid increase in [Ca2+]i and concomitant decrease in the capacity for carbachol-stimulated acid secretion in a dose dependent manner. Carbachol rapidly increased the [Ca2+]i from trimethoxybenzoic acid 8-(diethylamino)-octyl ester sensitive intracellular pool. In contrast, the increase with ethanol was through La3+ sensitive Ca2+ channel from external source, which suppressed the Ca2+ response subsequently stimulated with carbachol. Pretreatment of the cells with EGTA or La3+ completely prevented the elevation of [Ca2+]i with ethanol and preserved the Ca2+ response to carbachol. These findings indicate that ethanol-induced elevation of [Ca2+]i may desensitize the stimulation of carbachol. Furthermore, treatment of the parietal cells with ethanol increased the activity of protein kinase C in both cytosolic and membrane fractions of the cells. Activation of protein kinase C with phorbol diester suppressed the capacity for acid secretion. These results suggest that ethanol may inhibit the carbachol-stimulated acid secretion through the desensitization of Ca2+ response and the activation of protein kinase C. | lld:pubmed |
| pubmed-article:1404976 | pubmed:language | jpn | lld:pubmed |
| pubmed-article:1404976 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1404976 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1404976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1404976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1404976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1404976 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1404976 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1404976 | pubmed:issn | 0446-6586 | lld:pubmed |
| pubmed-article:1404976 | pubmed:author | pubmed-author:KawaiKK | lld:pubmed |
| pubmed-article:1404976 | pubmed:author | pubmed-author:NakamuraKK | lld:pubmed |
| pubmed-article:1404976 | pubmed:author | pubmed-author:SaitohTT | lld:pubmed |
| pubmed-article:1404976 | pubmed:author | pubmed-author:NikiSS | lld:pubmed |
| pubmed-article:1404976 | pubmed:author | pubmed-author:AoikeAA | lld:pubmed |
| pubmed-article:1404976 | pubmed:author | pubmed-author:KutsumiHH | lld:pubmed |
| pubmed-article:1404976 | pubmed:author | pubmed-author:OgiharaSS | lld:pubmed |
| pubmed-article:1404976 | pubmed:author | pubmed-author:RokutanKK | lld:pubmed |
| pubmed-article:1404976 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1404976 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:1404976 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1404976 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1404976 | pubmed:pagination | 1484-90 | lld:pubmed |
| pubmed-article:1404976 | pubmed:dateRevised | 2011-8-2 | lld:pubmed |
| pubmed-article:1404976 | pubmed:meshHeading | pubmed-meshheading:1404976-... | lld:pubmed |
| pubmed-article:1404976 | pubmed:meshHeading | pubmed-meshheading:1404976-... | lld:pubmed |
| pubmed-article:1404976 | pubmed:meshHeading | pubmed-meshheading:1404976-... | lld:pubmed |
| pubmed-article:1404976 | pubmed:meshHeading | pubmed-meshheading:1404976-... | lld:pubmed |
| pubmed-article:1404976 | pubmed:meshHeading | pubmed-meshheading:1404976-... | lld:pubmed |
| pubmed-article:1404976 | pubmed:meshHeading | pubmed-meshheading:1404976-... | lld:pubmed |
| pubmed-article:1404976 | pubmed:meshHeading | pubmed-meshheading:1404976-... | lld:pubmed |
| pubmed-article:1404976 | pubmed:meshHeading | pubmed-meshheading:1404976-... | lld:pubmed |
| pubmed-article:1404976 | pubmed:meshHeading | pubmed-meshheading:1404976-... | lld:pubmed |
| pubmed-article:1404976 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1404976 | pubmed:articleTitle | [Calcium-dependent signaling of acid secretion in isolated parietal cells from guinea pigs and its modification by ethanol]. | lld:pubmed |
| pubmed-article:1404976 | pubmed:affiliation | Department of Preventive Medicine, Kyoto Prefectural University of Medicine. | lld:pubmed |
| pubmed-article:1404976 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1404976 | pubmed:publicationType | English Abstract | lld:pubmed |
| pubmed-article:1404976 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
