| pubmed-article:1400293 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1400293 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:1400293 | lifeskim:mentions | umls-concept:C0054727 | lld:lifeskim |
| pubmed-article:1400293 | pubmed:issue | 28 | lld:pubmed |
| pubmed-article:1400293 | pubmed:dateCreated | 1992-11-16 | lld:pubmed |
| pubmed-article:1400293 | pubmed:abstractText | Carbovir (9-[4 alpha-(hydroxymethyl)cyclopent-2-ene-1 alpha-yl]guanine) (CBV) is a carbocyclic analogue of 2',3'-dideoxyguanosine that exhibits potent and selective in vitro activity against human immunodeficiency virus. Antiviral activity is associated with only the (-)-enantiomer. The transport characteristics of both (-)-CBV and (+)-CBV were investigated in human erythrocytes at 37 degrees C using a papaverine-stop assay. The influx of both enantiomers appeared saturable and was inhibited greater than 90% by a combination of adenine (a low Km permeant of the nucleobase carrier) and dilazep (a potent inhibitor of nucleoside transport). The influx of (-)-CBV and (+)-CBV proceeded primarily via the nucleobase carrier with Vmax (picomoles/second/5 microliters of cells)/Km (millimolar) values of 17/0.12 and 140/1.9, respectively. To a lesser extent, the influx of (-)-CBV and (+)-CBV also occurred via the nucleoside transporter. Although both compounds exhibited a similar low affinity for this latter carrier (Km approximately 2 mM), the Vmax for (-)-CBV influx was approximately 4-fold higher than the Vmax for (+)-CBV influx. We conclude that both CBV enantiomers enter human erythrocytes by two transporters that are enantiomerically selective. | lld:pubmed |
| pubmed-article:1400293 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1400293 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1400293 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1400293 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1400293 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1400293 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1400293 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1400293 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1400293 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:1400293 | pubmed:author | pubmed-author:ZimmermanT... | lld:pubmed |
| pubmed-article:1400293 | pubmed:author | pubmed-author:DominB ABA | lld:pubmed |
| pubmed-article:1400293 | pubmed:author | pubmed-author:MillerW HWH | lld:pubmed |
| pubmed-article:1400293 | pubmed:author | pubmed-author:DalugeS MSM | lld:pubmed |
| pubmed-article:1400293 | pubmed:author | pubmed-author:MahonyW BWB | lld:pubmed |
| pubmed-article:1400293 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1400293 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:1400293 | pubmed:volume | 267 | lld:pubmed |
| pubmed-article:1400293 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1400293 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1400293 | pubmed:pagination | 19792-7 | lld:pubmed |
| pubmed-article:1400293 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:1400293 | pubmed:meshHeading | pubmed-meshheading:1400293-... | lld:pubmed |
| pubmed-article:1400293 | pubmed:meshHeading | pubmed-meshheading:1400293-... | lld:pubmed |
| pubmed-article:1400293 | pubmed:meshHeading | pubmed-meshheading:1400293-... | lld:pubmed |
| pubmed-article:1400293 | pubmed:meshHeading | pubmed-meshheading:1400293-... | lld:pubmed |
| pubmed-article:1400293 | pubmed:meshHeading | pubmed-meshheading:1400293-... | lld:pubmed |
| pubmed-article:1400293 | pubmed:meshHeading | pubmed-meshheading:1400293-... | lld:pubmed |
| pubmed-article:1400293 | pubmed:meshHeading | pubmed-meshheading:1400293-... | lld:pubmed |
| pubmed-article:1400293 | pubmed:meshHeading | pubmed-meshheading:1400293-... | lld:pubmed |
| pubmed-article:1400293 | pubmed:meshHeading | pubmed-meshheading:1400293-... | lld:pubmed |
| pubmed-article:1400293 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1400293 | pubmed:articleTitle | Enantiomeric selectivity of carbovir transport. | lld:pubmed |
| pubmed-article:1400293 | pubmed:affiliation | Division of Experimental Therapy, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709. | lld:pubmed |
| pubmed-article:1400293 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1400293 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1400293 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1400293 | lld:pubmed |
