| pubmed-article:1395102 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1395102 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:1395102 | lifeskim:mentions | umls-concept:C0020966 | lld:lifeskim |
| pubmed-article:1395102 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1395102 | lifeskim:mentions | umls-concept:C0019409 | lld:lifeskim |
| pubmed-article:1395102 | lifeskim:mentions | umls-concept:C0205228 | lld:lifeskim |
| pubmed-article:1395102 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1395102 | pubmed:dateCreated | 1992-11-5 | lld:pubmed |
| pubmed-article:1395102 | pubmed:abstractText | A characteristic feature associated with HIV-1 infection of the human host is a chronic decline in circulating CD4+ T helper/inducer cell numbers. Impaired cell-mediated immune functions usually occur in parallel with the decline in CD4+ T cells. Activated CD4+ T helper cells are a major source of endogenous IL-2 which is required for the immunoregulation of both antigen-specific B cells and CD8+ T cells. HIV-specific T cell proliferative responses are said to be weak and inconsistent, even during the asymptomatic phase of disease. We thus wished to determine how exogenous IL-2 affected HIV-specific T cell proliferation at different stages of the disease. Our cohort of 81 included both asymptomatic and symptomatic HIV-infected patients as well as uninfected normal donors. Proliferative responses of peripheral blood mononuclear cells (PBMC) that were elicited during culture with an immunodominant gp41-derived synthetic peptide, gp41[8], and which were known to be CD8+ cell-associated in asymptomatics only, were used to analyse the effects of exogenous IL-2. IL-2 had three main effects on HIV-specific proliferation, namely (i) an additive effect, (ii) a synergistic effect, and (iii) an induced effect. More specifically, low dose exogenous IL-2 frequently augmented lymphoproliferation in both asymptomatic and symptomatic gp41[8] responders. In most symptomatics, however, who were predominantly gp41[8] non-responders, exogenous IL-2 induced lymphoproliferation. Flow cytometric analyses using dual immunofluorescence were used to analyse the T cell subset distribution of proliferating PBMC cultures. During culture with gp41[8], both CD4+ and CD8+ T cell numbers increased. However, after the addition of exogenous IL-2 to gp41[8]-containing cultures, CD8+ cell-associated lymphoproliferative responses were preferentially augmented. These results suggest that in symptomatics there is an inadequate supply of endogenous IL-2 to help maintain the strong and effective CD8+ cell-associated anti-viral immunity, and an exogenous supply of IL-2 may be required. | lld:pubmed |
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| pubmed-article:1395102 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1395102 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1395102 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1395102 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1395102 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1395102 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:1395102 | pubmed:author | pubmed-author:KempB EBE | lld:pubmed |
| pubmed-article:1395102 | pubmed:author | pubmed-author:PennyRR | lld:pubmed |
| pubmed-article:1395102 | pubmed:author | pubmed-author:CooperD ADA | lld:pubmed |
| pubmed-article:1395102 | pubmed:author | pubmed-author:BellS JSJ | lld:pubmed |
| pubmed-article:1395102 | pubmed:author | pubmed-author:DohertyR RRR | lld:pubmed |
| pubmed-article:1395102 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1395102 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:1395102 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1395102 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1395102 | pubmed:pagination | 6-12 | lld:pubmed |
| pubmed-article:1395102 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
| pubmed-article:1395102 | pubmed:meshHeading | pubmed-meshheading:1395102-... | lld:pubmed |
| pubmed-article:1395102 | pubmed:meshHeading | pubmed-meshheading:1395102-... | lld:pubmed |
| pubmed-article:1395102 | pubmed:meshHeading | pubmed-meshheading:1395102-... | lld:pubmed |
| pubmed-article:1395102 | pubmed:meshHeading | pubmed-meshheading:1395102-... | lld:pubmed |
| pubmed-article:1395102 | pubmed:meshHeading | pubmed-meshheading:1395102-... | lld:pubmed |
| pubmed-article:1395102 | pubmed:meshHeading | pubmed-meshheading:1395102-... | lld:pubmed |
| pubmed-article:1395102 | pubmed:meshHeading | pubmed-meshheading:1395102-... | lld:pubmed |
| pubmed-article:1395102 | pubmed:meshHeading | pubmed-meshheading:1395102-... | lld:pubmed |
| pubmed-article:1395102 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1395102 | pubmed:articleTitle | Heterogeneous effects of exogenous IL-2 on HIV-specific cell-mediated immunity (CMI). | lld:pubmed |
| pubmed-article:1395102 | pubmed:affiliation | Centre for Immunology, St Vincent's Hospital, Sydney, Australia. | lld:pubmed |
| pubmed-article:1395102 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1395102 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1395102 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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