Linked Life Data

1383252

Source:http://linkedlifedata.com/resource/pubmed/id/1383252

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SubjectPredicateObjectContext
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pubmed-article:1383252pubmed:abstractTextHigh-performance liquid chromatography has become an important analytical tool for the quantitation of opioid drugs. Using solid-phase extraction and coulometric electrochemical detection, we have developed a chromatographic method for the simultaneous measurement of morphine and hydromorphone which is both sensitive and specific. Using 1 ml of plasma, intra-assay and inter-assay data show that the detection limit for accurate quantitation of these compounds is about 1.2 ng/ml (coefficient of variation 11.6%) for morphine and 2.5 ng/ml (coefficient of variation 10.5%) for hydromorphone. The method is simple and readily adaptable to most pharmacokinetic studies and toxic screens involving these drugs.lld:pubmed
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pubmed-article:1383252pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:1383252pubmed:articleTitleSimultaneous solid-phase extraction and chromatographic analysis of morphine and hydromorphone in plasma by high-performance liquid chromatography with electrochemical detection.lld:pubmed
pubmed-article:1383252pubmed:affiliationDepartment of Clinical Neurological Sciences, University of Western Ontario, Victoria Hospital, London, Canada.lld:pubmed
pubmed-article:1383252pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1383252pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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