| pubmed-article:1379232 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1379232 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:1379232 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:1379232 | lifeskim:mentions | umls-concept:C0035679 | lld:lifeskim |
| pubmed-article:1379232 | lifeskim:mentions | umls-concept:C1519591 | lld:lifeskim |
| pubmed-article:1379232 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:1379232 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:1379232 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:1379232 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:1379232 | pubmed:dateCreated | 1992-8-28 | lld:pubmed |
| pubmed-article:1379232 | pubmed:abstractText | Regulation of transcription elongation is an important mechanism in controlling eukaryotic gene expression. SII is an RNA polymerase II-binding protein that stimulates transcription elongation and also activates nascent transcript cleavage by RNA polymerase II in elongation complexes in vitro (Reines, D. (1992) J. Biol. Chem. 267, 3795-3800). Here we show that SII-dependent in vitro transcription through an arrest site in a human gene is preceded by nascent transcript cleavage. RNA cleavage appeared to be an obligatory step in the SII activation process. Recombinant SII activated cleavage while a truncated derivative lacking polymerase binding activity did not. Cleavage was not restricted to an elongation complex arrested at this particular site, showing that nascent RNA hydrolysis is a general property of RNA polymerase II elongation complexes. These data support a model whereby SII stimulates elongation via a ribonuclease activity of the elongation complex. | lld:pubmed |
| pubmed-article:1379232 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1379232 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1379232 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1379232 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1379232 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1379232 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1379232 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1379232 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1379232 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1379232 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:1379232 | pubmed:author | pubmed-author:ReinerGG | lld:pubmed |
| pubmed-article:1379232 | pubmed:author | pubmed-author:LiQ QQQ | lld:pubmed |
| pubmed-article:1379232 | pubmed:author | pubmed-author:MoteJJJr | lld:pubmed |
| pubmed-article:1379232 | pubmed:author | pubmed-author:GhanouniPP | lld:pubmed |
| pubmed-article:1379232 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1379232 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:1379232 | pubmed:volume | 267 | lld:pubmed |
| pubmed-article:1379232 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1379232 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1379232 | pubmed:pagination | 15516-22 | lld:pubmed |
| pubmed-article:1379232 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1379232 | pubmed:meshHeading | pubmed-meshheading:1379232-... | lld:pubmed |
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| pubmed-article:1379232 | pubmed:meshHeading | pubmed-meshheading:1379232-... | lld:pubmed |
| pubmed-article:1379232 | pubmed:meshHeading | pubmed-meshheading:1379232-... | lld:pubmed |
| pubmed-article:1379232 | pubmed:meshHeading | pubmed-meshheading:1379232-... | lld:pubmed |
| pubmed-article:1379232 | pubmed:meshHeading | pubmed-meshheading:1379232-... | lld:pubmed |
| pubmed-article:1379232 | pubmed:meshHeading | pubmed-meshheading:1379232-... | lld:pubmed |
| pubmed-article:1379232 | pubmed:meshHeading | pubmed-meshheading:1379232-... | lld:pubmed |
| pubmed-article:1379232 | pubmed:meshHeading | pubmed-meshheading:1379232-... | lld:pubmed |
| pubmed-article:1379232 | pubmed:meshHeading | pubmed-meshheading:1379232-... | lld:pubmed |
| pubmed-article:1379232 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1379232 | pubmed:articleTitle | The RNA polymerase II elongation complex. Factor-dependent transcription elongation involves nascent RNA cleavage. | lld:pubmed |
| pubmed-article:1379232 | pubmed:affiliation | Graduate Program in Biochemistry and Molecular Biology, Emory University School of Medicine, Atlanta, Georgia 30322. | lld:pubmed |
| pubmed-article:1379232 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1379232 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1379232 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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