| pubmed-article:1378341 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1378341 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:1378341 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:1378341 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:1378341 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:1378341 | lifeskim:mentions | umls-concept:C1267092 | lld:lifeskim |
| pubmed-article:1378341 | lifeskim:mentions | umls-concept:C1522720 | lld:lifeskim |
| pubmed-article:1378341 | lifeskim:mentions | umls-concept:C0205462 | lld:lifeskim |
| pubmed-article:1378341 | lifeskim:mentions | umls-concept:C0682132 | lld:lifeskim |
| pubmed-article:1378341 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:1378341 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:1378341 | lifeskim:mentions | umls-concept:C1321564 | lld:lifeskim |
| pubmed-article:1378341 | lifeskim:mentions | umls-concept:C1140999 | lld:lifeskim |
| pubmed-article:1378341 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1378341 | pubmed:dateCreated | 1992-8-20 | lld:pubmed |
| pubmed-article:1378341 | pubmed:abstractText | 1. Parenchymal lung strip preparations have been widely used as an in vitro model of peripheral airway smooth muscle. The present study examined functional responses of 4 consecutive guinea-pig lung parenchymal strips isolated from the central region (segment 1) to the distal edge (segment 4) of the lower lung lobe. The middle two segments were designated as segments 2 and 3. 2. Lung segments 1 and 4 exhibited significantly greater contraction than the other 2 segments to KCl when responses were expressed as mg force per mg tissue weight. Contractile responses to bronchospastic agents including histamine, carbachol, endothelin-1, leukotrienes (LT) B4 and D4, and the thromboxane A2-mimetic U46619 demonstrated no significant difference in EC50 values among the 4 lung segments. 3. Contractile responses of segments 1 and 4 to antigen-challenge (ovalbumin), ionophore A23187 and substance P were significantly greater than the other 2 segments with respect to either sensitivity or maximum responsiveness. 4. U46619-induced contractions of the 4 lung segments were relaxed in similar manner by papaverine and theophylline up to 100%, salbutamol up to 80%, and sodium nitroprusside by only 20%. In contrast, sodium nitroprusside markedly reversed U46619-induced contraction of pulmonary arterial rings and bronchial rings. 5. Histological studies identified 2-4 layers of smooth muscle cells underlying the lung pleural surface. Mast cells were prominent in this area. Moreover, morphometric studies showed that segment 4 possessed the least amount of smooth muscle structures from bronchial/bronchiolar wall and vasculatures as compared to the other 3 segments, and a significant difference in this respect was evident between segment 1 and segment 4.6. Since lung segments 1 and 4 are covered with larger surface area of lung pleura, the present results suggest that the significantly greater intrinsic contractile responses of segments 1 and 4 are associated with the presence of increased lung pleural surface possibly together with more mast cells. Thus, a primary contribution to the net contraction of the lung parenchymal strips may be smooth muscle from the lung pleura, alveolar ducts and interstitial contractile cells rather than from bronchi/bronchioles and microvasculatures. | lld:pubmed |
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| pubmed-article:1378341 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1378341 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1378341 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1378341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1378341 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1378341 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1378341 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:1378341 | pubmed:author | pubmed-author:FleischJ HJH | lld:pubmed |
| pubmed-article:1378341 | pubmed:author | pubmed-author:WongW SWS | lld:pubmed |
| pubmed-article:1378341 | pubmed:author | pubmed-author:BendeleA MAM | lld:pubmed |
| pubmed-article:1378341 | pubmed:author | pubmed-author:BloomquistS... | lld:pubmed |
| pubmed-article:1378341 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1378341 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:1378341 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1378341 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1378341 | pubmed:pagination | 620-6 | lld:pubmed |
| pubmed-article:1378341 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
| pubmed-article:1378341 | pubmed:meshHeading | pubmed-meshheading:1378341-... | lld:pubmed |
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| pubmed-article:1378341 | pubmed:meshHeading | pubmed-meshheading:1378341-... | lld:pubmed |
| pubmed-article:1378341 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1378341 | pubmed:articleTitle | Pharmacological and histological examinations of regional differences of guinea-pig lung: a role of pleural surface smooth muscle in lung strip contraction. | lld:pubmed |
| pubmed-article:1378341 | pubmed:affiliation | Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285. | lld:pubmed |
| pubmed-article:1378341 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1378341 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1378341 | lld:pubmed |
