| pubmed-article:1370433 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1370433 | lifeskim:mentions | umls-concept:C0038409 | lld:lifeskim |
| pubmed-article:1370433 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1370433 | lifeskim:mentions | umls-concept:C0025252 | lld:lifeskim |
| pubmed-article:1370433 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:1370433 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:1370433 | lifeskim:mentions | umls-concept:C0017263 | lld:lifeskim |
| pubmed-article:1370433 | lifeskim:mentions | umls-concept:C0597551 | lld:lifeskim |
| pubmed-article:1370433 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1370433 | pubmed:dateCreated | 1992-2-18 | lld:pubmed |
| pubmed-article:1370433 | pubmed:abstractText | The immune responses to a cell surface protein antigen (PAc) of Streptococcus mutans and a peptide corresponding to residues 301 to 319 of the protein antigen [PAc(301-319)] in various strains of mice were studied, with attention being given to the haplotype of major histocompatibility complex (MHC) class II genes. Subcutaneous immunization of mice carrying the MHC class II I-Ad gene [BALB/c, B10.D2, B10.GD, and (B10.D2 x B10.G)F1 mice] with the peptide induced strong serum immunoglobulin G (IgG) responses to recombinant PAc (rPAc) and the peptide. Subcutaneous immunization of mice carrying the haplotype k or b of the H-2 I-A gene (C3H/HeN, C57BL/6, B10.BR, B10.A, or B10 mice) with the peptide induced intermediate serum IgG responses to rPAc and the peptide, and subcutaneous immunization of mice carrying the haplotype s or q of the H-2 I-A gene (DBA/1, B10.S, or B10.G mice) induced weak serum IgG responses to rPAc and the peptide compared with the responses of mice carrying the I-Ad gene. PAc(301-319) strongly induced PAc(301-319)-specific T-cell proliferation in B10.D2 mice but not in B10.G mice. The T-cell proliferation in B10.D2 mice was inhibited by treatment of antigen-presenting cells with anti-I-Ad monoclonal antibody but not with anti-I-Ab monoclonal antibody. These results indicate that the immune responses to the peptide in mice are genetically restricted or dominated by the MHC class II gene (I-Ad). To map antigenic epitopes in PAc(301-319) and PAc in mice bearing different H-2 haplotypes, 10 overlapping decapeptides covering PAc(301-319) and 153 decapeptides covering the entire mature PAc were synthesized. Of 10 decapeptides covering PAc(301-319), 6, 7, 1, and 1 decapeptides showed strong reactions with anti-PAc(301-319) sera from B10.D2 (H-2d), B10.GD (H-2g2), B10.BR (H-2k), and B10.A (H-2a) mice, respectively. None of these overlapping decapeptides reacted with anti-PAc(301-319) sera from B10.S (H-2s) and B10.G (H-2q) mice. Epitope-scanning analyses of the mature PAc molecule showed that antigenic epitopes scattered throughout the molecule and that antigenic epitope patterns differed in mice with different H-2 haplotypes. In addition, there was little overlap of immunogenic peptides among the mice with different haplotypes. | lld:pubmed |
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| pubmed-article:1370433 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1370433 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1370433 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1370433 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1370433 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:1370433 | pubmed:author | pubmed-author:SuzukiYY | lld:pubmed |
| pubmed-article:1370433 | pubmed:author | pubmed-author:MatsushitaKK | lld:pubmed |
| pubmed-article:1370433 | pubmed:author | pubmed-author:RussellM WMW | lld:pubmed |
| pubmed-article:1370433 | pubmed:author | pubmed-author:NisizawaTT | lld:pubmed |
| pubmed-article:1370433 | pubmed:author | pubmed-author:TakahashiII | lld:pubmed |
| pubmed-article:1370433 | pubmed:author | pubmed-author:KogaTT | lld:pubmed |
| pubmed-article:1370433 | pubmed:author | pubmed-author:MunekataEE | lld:pubmed |
| pubmed-article:1370433 | pubmed:author | pubmed-author:OkahashiNN | lld:pubmed |
| pubmed-article:1370433 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1370433 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:1370433 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1370433 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1370433 | pubmed:pagination | 623-9 | lld:pubmed |
| pubmed-article:1370433 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1370433 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1370433 | pubmed:articleTitle | Genetic control of immune responses in mice to synthetic peptides of a Streptococcus mutans surface protein antigen. | lld:pubmed |
| pubmed-article:1370433 | pubmed:affiliation | Department of Dental Research, National Institute of Health, Tokyo, Japan. | lld:pubmed |
| pubmed-article:1370433 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1370433 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1370433 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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