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pubmed-article:1366420pubmed:abstractTextThe iron-binding plasma protein transferrin (TF) is essential for supplying iron to cells and the prevention of iron toxicity. Our laboratory has cloned and characterized the human TF gene. Comparison of promoter regions of TF genes from human, chicken, and mouse reveals a strong nucleotide sequence conservation. This study demonstrates that 5' flanking regions of the TF gene are sufficient for directing expression of a heterologous gene in transgenic mice and transfected cells. For cell-specific expression, more than 150 base pairs appear to be required.lld:pubmed
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pubmed-article:1366420pubmed:articleTitleExpression of chimeric human transferrin genes in transfected human tumor cell lines.lld:pubmed
pubmed-article:1366420pubmed:affiliationDepartment of Cellular & Structural Biology, University of Texas Health Science Center, San Antonio 78284.lld:pubmed
pubmed-article:1366420pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1366420pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:1366420pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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