| pubmed-article:1346064 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1346064 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:1346064 | lifeskim:mentions | umls-concept:C0025932 | lld:lifeskim |
| pubmed-article:1346064 | lifeskim:mentions | umls-concept:C1955941 | lld:lifeskim |
| pubmed-article:1346064 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:1346064 | lifeskim:mentions | umls-concept:C2347644 | lld:lifeskim |
| pubmed-article:1346064 | pubmed:issue | 6356 | lld:pubmed |
| pubmed-article:1346064 | pubmed:dateCreated | 1992-2-12 | lld:pubmed |
| pubmed-article:1346064 | pubmed:abstractText | T lymphocytes expressing alpha beta T-cell receptors with sufficient affinity to major histocompatibility complex (MHC) molecules expressed on thymus epithelial cells are positively selected and mature to functional T cells. But several studies have demonstrated that athymic nude mice grafted with MHC-incompatible thymuses developed T cells specific for nude host rather than thymic MHC. We examined this paradox by analysing the specificity of T lymphocytes derived from nude mice. We report here that nude T lymphocyte precursors transferred to allogeneic SCID (severe combined immunodeficiency) mice with a functioning thymus (but lacking T or B cells) generated host MHC-restricted effector T cells but also contained T cells restricted to donor MHC. If nude T cells were depleted from nude lymphohaemopoietic donor cells before or after transfer, only host MHC-specific T cells matured. The results may explain the unusual MHC specificities of nude T lymphocytes described in earlier studies and demonstrate two separate differentiation steps: in nude mice, T cells may be positively selected for self-MHC restriction specificity extrathymically; then a functional thymus is required for efficient T cell maturation. | lld:pubmed |
| pubmed-article:1346064 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1346064 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1346064 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1346064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1346064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1346064 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1346064 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1346064 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:1346064 | pubmed:author | pubmed-author:ZinkernagelR... | lld:pubmed |
| pubmed-article:1346064 | pubmed:author | pubmed-author:SpeiserD EDE | lld:pubmed |
| pubmed-article:1346064 | pubmed:author | pubmed-author:StübiUU | lld:pubmed |
| pubmed-article:1346064 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1346064 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:1346064 | pubmed:volume | 355 | lld:pubmed |
| pubmed-article:1346064 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1346064 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1346064 | pubmed:pagination | 170-2 | lld:pubmed |
| pubmed-article:1346064 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1346064 | pubmed:meshHeading | pubmed-meshheading:1346064-... | lld:pubmed |
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| pubmed-article:1346064 | pubmed:meshHeading | pubmed-meshheading:1346064-... | lld:pubmed |
| pubmed-article:1346064 | pubmed:meshHeading | pubmed-meshheading:1346064-... | lld:pubmed |
| pubmed-article:1346064 | pubmed:meshHeading | pubmed-meshheading:1346064-... | lld:pubmed |
| pubmed-article:1346064 | pubmed:meshHeading | pubmed-meshheading:1346064-... | lld:pubmed |
| pubmed-article:1346064 | pubmed:meshHeading | pubmed-meshheading:1346064-... | lld:pubmed |
| pubmed-article:1346064 | pubmed:meshHeading | pubmed-meshheading:1346064-... | lld:pubmed |
| pubmed-article:1346064 | pubmed:meshHeading | pubmed-meshheading:1346064-... | lld:pubmed |
| pubmed-article:1346064 | pubmed:meshHeading | pubmed-meshheading:1346064-... | lld:pubmed |
| pubmed-article:1346064 | pubmed:meshHeading | pubmed-meshheading:1346064-... | lld:pubmed |
| pubmed-article:1346064 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1346064 | pubmed:articleTitle | Extrathymic positive selection of alpha beta T-cell precursors in nude mice. | lld:pubmed |
| pubmed-article:1346064 | pubmed:affiliation | Laboratory for Experimental Pathology, University Hospital, Zürich, Switzerland. | lld:pubmed |
| pubmed-article:1346064 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1346064 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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