| pubmed-article:1335504 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1335504 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:1335504 | lifeskim:mentions | umls-concept:C0040704 | lld:lifeskim |
| pubmed-article:1335504 | lifeskim:mentions | umls-concept:C0687129 | lld:lifeskim |
| pubmed-article:1335504 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:1335504 | lifeskim:mentions | umls-concept:C0036226 | lld:lifeskim |
| pubmed-article:1335504 | lifeskim:mentions | umls-concept:C2334101 | lld:lifeskim |
| pubmed-article:1335504 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:1335504 | lifeskim:mentions | umls-concept:C1550548 | lld:lifeskim |
| pubmed-article:1335504 | lifeskim:mentions | umls-concept:C1555714 | lld:lifeskim |
| pubmed-article:1335504 | lifeskim:mentions | umls-concept:C1705654 | lld:lifeskim |
| pubmed-article:1335504 | pubmed:dateCreated | 1993-2-2 | lld:pubmed |
| pubmed-article:1335504 | pubmed:abstractText | 1. Single atrial myocytes obtained by enzyme perfusion from hearts of adult guinea-pigs were investigated using whole-cell voltage clamp and Indo-1 micro-fluorometry. 2. In myocytes loaded with a solution containing citrate as a low-affinity, non-saturable Ca2+ chelator, two types of [Ca2+]i transients could be recorded during repetitive activation of L-type Ca2+ current. Both large and small [Ca2+]i transients occurred; large transients reached peak values of about 1 microM, and small transients were about 100 nM or less in amplitude. 3. In the case of the large transients, peak [Ca2+]i was usually reached with a variable delay after repolarization from a voltage step that activated calcium current (ICa). For the small transients the rise in [Ca2+]i paralleled ICa. Upon repolarization [Ca2+]i started to decay. 4. The small transients reflect entry of Ca2+ through Ca2+ channels (entry transients), whereas the large transients are due to entry and release from the sarcoplasmic reticulum (release transients). 5. The entry transients displayed a positive staircase pattern during trains of depolarizing voltage steps despite constant or even decreasing amplitude of ICa. The steepness of the staircase was increased by elevation of [Ca2+]o. Entry transients were always smallest immediately after a release transient. 6. After functional removal of the sarcoplasmic reticulum by caffeine (1-5 mM) the staircase pattern of the transients reflecting Ca2+ entry was abolished. 7. It is concluded that the staircase pattern is due to rapid uptake by the sarcoplasmic reticulum of Ca2+ entering the cell, resulting in an attenuation of the signal. The attenuation is strongest shortly after a release signal, when the rate of sequestration of Ca2+ by the SR should be highest. 8. Evidence is provided that a compartment of the SR is involved in attenuation of the entry transients. This compartment has been identified recently as a peripheral release compartment. | lld:pubmed |
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| pubmed-article:1335504 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1335504 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1335504 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1335504 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1335504 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1335504 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:1335504 | pubmed:author | pubmed-author:CarmelietEE | lld:pubmed |
| pubmed-article:1335504 | pubmed:author | pubmed-author:PostSS | lld:pubmed |
| pubmed-article:1335504 | pubmed:author | pubmed-author:CallewaertGG | lld:pubmed |
| pubmed-article:1335504 | pubmed:author | pubmed-author:LippPP | lld:pubmed |
| pubmed-article:1335504 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1335504 | pubmed:volume | 454 | lld:pubmed |
| pubmed-article:1335504 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1335504 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1335504 | pubmed:pagination | 321-38 | lld:pubmed |
| pubmed-article:1335504 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1335504 | pubmed:meshHeading | pubmed-meshheading:1335504-... | lld:pubmed |
| pubmed-article:1335504 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1335504 | pubmed:articleTitle | Calcium transients caused by calcium entry are influenced by the sarcoplasmic reticulum in guinea-pig atrial myocytes. | lld:pubmed |
| pubmed-article:1335504 | pubmed:affiliation | Laboratory of Physiology, Catholic University Leuven, Belgium. | lld:pubmed |
| pubmed-article:1335504 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1335504 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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