| pubmed-article:1329657 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1329657 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:1329657 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:1329657 | lifeskim:mentions | umls-concept:C0136157 | lld:lifeskim |
| pubmed-article:1329657 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1329657 | pubmed:dateCreated | 1992-11-13 | lld:pubmed |
| pubmed-article:1329657 | pubmed:abstractText | Peroxynitrite formation by rat alveolar macrophages activated with phorbol 12-myristate 13-acetate was assayed by the Cu,Zn superoxide dismutase-catalyzed nitration of 4-hydroxyphenylacetate. The inhibitor of nitric oxide synthesis N-methyl-L-arginine prevented the Cu,Zn superoxide dismutase-catalyzed nitration of 4-hydroxyphenylacetate by stimulated macrophages, while Cu-depleted Zn superoxide dismutase did not catalyze the formation of 3-nitro-4-hydroxyphenylacetate either in vitro or in the presence of activated macrophages. The rate of phenolic nitration by activated macrophages was 9 +/- 2 pmol x 10(6) cells-1 x min-1 (mean +/- STD). Only 8% of synthetic peroxynitrite was trapped by superoxide dismutase, which suggested that the rate of peroxynitrite formation may have been as high as 0.11 nmol x 10(6) cells-1 x min-1. This upper estimate was consistent with N-methyl-L-arginine increasing the amount of superoxide detected with cytochrome c by 0.12 nmol x 10(6) cells-1 x min-1. The rate of nitrite and nitrate accumulation was 0.10 +/- 0.001 nmol x 10(6) cells-1 x min-1, suggesting that the majority of nitric oxide produced by activated macrophages may have been converted to peroxynitrite. The formation of a relatively long lived, strong oxidant from the reaction of nitric oxide and superoxide in activated macrophages may contribute to inflammatory cell-mediated tissue injury. | lld:pubmed |
| pubmed-article:1329657 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1329657 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1329657 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1329657 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1329657 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1329657 | pubmed:issn | 0003-9861 | lld:pubmed |
| pubmed-article:1329657 | pubmed:author | pubmed-author:BeckmanJ SJS | lld:pubmed |
| pubmed-article:1329657 | pubmed:author | pubmed-author:ZinTT | lld:pubmed |
| pubmed-article:1329657 | pubmed:author | pubmed-author:Ischiropoulos... | lld:pubmed |
| pubmed-article:1329657 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1329657 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1329657 | pubmed:volume | 298 | lld:pubmed |
| pubmed-article:1329657 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1329657 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1329657 | pubmed:pagination | 446-51 | lld:pubmed |
| pubmed-article:1329657 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1329657 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1329657 | pubmed:articleTitle | Peroxynitrite formation from macrophage-derived nitric oxide. | lld:pubmed |
| pubmed-article:1329657 | pubmed:affiliation | Department of Anesthesiology, University of Alabama, Birmingham 35294. | lld:pubmed |
| pubmed-article:1329657 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1329657 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1329657 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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