| pubmed-article:1322348 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1322348 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:1322348 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:1322348 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:1322348 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
| pubmed-article:1322348 | lifeskim:mentions | umls-concept:C0017431 | lld:lifeskim |
| pubmed-article:1322348 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:1322348 | lifeskim:mentions | umls-concept:C0032520 | lld:lifeskim |
| pubmed-article:1322348 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:1322348 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:1322348 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:1322348 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:1322348 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1322348 | pubmed:dateCreated | 1992-9-2 | lld:pubmed |
| pubmed-article:1322348 | pubmed:abstractText | To investigate the relationship between genotypes of hepatitis C virus and response to interferon-alpha therapy, hepatitis C virus RNA was assayed by polymerase chain reaction with three sets of primers and probes in 70 patients with non-A, non-B chronic hepatitis who received interferon-alpha. Twenty-four patients sustained long-term remissions (complete responders). Polymerase chain reaction for 5'-terminal noncoding region detected hepatitis C virus RNA in 94.3% (66 of 70) of the patients. Polymerase chain reaction for nonstructural region 3, in which primers and a probe were synthesized to be identical to hepatitis C virus-J, detected hepatitis C virus RNA in 40 patients. Polymerase chain reaction for nonstructural region 5-in which sequences of primers and a probe were derived from hepatitis C virus-K2, a genotype different from hepatitis C virus-J--detected hepatitis C virus RNA in 17 patients. Only one patient was positive on both nonstructural region 3 and nonstructural region 5 polymerase chain reaction. Nucleotide sequence of clones obtained from 5' terminal noncoding region polymerase chain reaction products of two patients positive on polymerase chain reaction for nonstructural region 3 and negative on polymerase chain reaction for nonstructural region 5 (group 1) corresponded to that of the hepatitis C virus-J group, and those of clones from two patients negative on polymerase chain reaction for nonstructural region 3 and positive on polymerase chain reaction for nonstructural region 5 (group 2) corresponded to that of hepatitis C virus-K2.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1322348 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1322348 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1322348 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1322348 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1322348 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1322348 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1322348 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1322348 | pubmed:issn | 0270-9139 | lld:pubmed |
| pubmed-article:1322348 | pubmed:author | pubmed-author:ItohYY | lld:pubmed |
| pubmed-article:1322348 | pubmed:author | pubmed-author:IshikawaTT | lld:pubmed |
| pubmed-article:1322348 | pubmed:author | pubmed-author:YoshiokaKK | lld:pubmed |
| pubmed-article:1322348 | pubmed:author | pubmed-author:MorishimaTT | lld:pubmed |
| pubmed-article:1322348 | pubmed:author | pubmed-author:KakumuSS | lld:pubmed |
| pubmed-article:1322348 | pubmed:author | pubmed-author:ShibataMM | lld:pubmed |
| pubmed-article:1322348 | pubmed:author | pubmed-author:HigashiYY | lld:pubmed |
| pubmed-article:1322348 | pubmed:author | pubmed-author:TakayanagiMM | lld:pubmed |
| pubmed-article:1322348 | pubmed:author | pubmed-author:WakitaTT | lld:pubmed |
| pubmed-article:1322348 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1322348 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:1322348 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1322348 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1322348 | pubmed:pagination | 293-9 | lld:pubmed |
| pubmed-article:1322348 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:1322348 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1322348 | pubmed:articleTitle | Detection of hepatitis C virus by polymerase chain reaction and response to interferon-alpha therapy: relationship to genotypes of hepatitis C virus. | lld:pubmed |
| pubmed-article:1322348 | pubmed:affiliation | Third Department of Internal Medicine, Nagoya University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:1322348 | pubmed:publicationType | Journal Article | lld:pubmed |
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