Linked Life Data

1309795

Source:http://linkedlifedata.com/resource/pubmed/id/1309795

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:1309795rdf:typepubmed:Citationlld:pubmed
pubmed-article:1309795lifeskim:mentionsumls-concept:C0010453lld:lifeskim
pubmed-article:1309795lifeskim:mentionsumls-concept:C0034721lld:lifeskim
pubmed-article:1309795lifeskim:mentionsumls-concept:C0034693lld:lifeskim
pubmed-article:1309795lifeskim:mentionsumls-concept:C0227525lld:lifeskim
pubmed-article:1309795lifeskim:mentionsumls-concept:C0178539lld:lifeskim
pubmed-article:1309795lifeskim:mentionsumls-concept:C0021467lld:lifeskim
pubmed-article:1309795lifeskim:mentionsumls-concept:C1314792lld:lifeskim
pubmed-article:1309795lifeskim:mentionsumls-concept:C0441889lld:lifeskim
pubmed-article:1309795lifeskim:mentionsumls-concept:C1157380lld:lifeskim
pubmed-article:1309795lifeskim:mentionsumls-concept:C0043791lld:lifeskim
pubmed-article:1309795lifeskim:mentionsumls-concept:C0021469lld:lifeskim
pubmed-article:1309795lifeskim:mentionsumls-concept:C0547047lld:lifeskim
pubmed-article:1309795lifeskim:mentionsumls-concept:C0439596lld:lifeskim
pubmed-article:1309795lifeskim:mentionsumls-concept:C0332120lld:lifeskim
pubmed-article:1309795pubmed:issue3lld:pubmed
pubmed-article:1309795pubmed:dateCreated1992-2-18lld:pubmed
pubmed-article:1309795pubmed:abstractTextThe mechanism by which glucagon and cAMP analogues inhibit phosphatidylcholine biosynthesis was investigated in rat hepatocytes. The studies were facilitated by preparation of an antibody to a synthetic peptide (D-F-V-A-H-D-D-I-P-Y-S-S-A) corresponding to residues 164-176 of CTP:phosphocholine cytidylyl-transferase. The antibody, which was purified by affinity chromatography, quantitatively immunoprecipitated cytidylyltransferase from rat liver cytosol. Various analogues of cAMP had no effect on the labeling of cytidylyltransferase with 32Pi in rat hepatocytes. Nor did the cAMP analogues have any effect on the distribution of cytidylyltransferase between cytosol and membranes. These results indicate that the supply of CDP-choline does not limit phosphatidylcholine biosynthesis in hepatocytes treated with cAMP analogues. A decreased supply of diacylglycerol was considered as an alternative mechanism for inhibition of phosphatidylcholine biosynthesis. An approximately 30% decrease in diacylglycerol concentration was observed in hepatocytes treated with the cAMP analogues or glucagon, compared with controls. A similar decrease of phosphatidylcholine biosynthesis was observed. The cAMP-mediated decrease in diacylglycerol levels and inhibition of phosphatidylcholine biosynthesis were reversed by addition of 0.5-1.5 mM oleic acid to the treated hepatocytes. A correlation coefficient of 0.93 was calculated between the levels of diacylglycerol and the rate of phosphatidylcholine biosynthesis. In another approach, the diacylglycerol levels were increased by an inhibitor of diacylglycerol lipase (U-57908) which also reversed the cAMP effects on diacylglycerol levels and phosphatidylcholine biosynthesis. We conclude that the cAMP-mediated inhibition of phosphatidylcholine biosynthesis was not due to an effect on the phosphorylation of cytidylyltransferase. Instead, phosphatidylcholine biosynthesis appears to be inhibited due to a decreased level of diacylglycerol, a substrate for CDP-choline: 1,2-diacylglycerol cholinephosphotransferase.lld:pubmed
pubmed-article:1309795pubmed:languageenglld:pubmed
pubmed-article:1309795pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:citationSubsetIMlld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1309795pubmed:statusMEDLINElld:pubmed
pubmed-article:1309795pubmed:monthJanlld:pubmed
pubmed-article:1309795pubmed:issn0021-9258lld:pubmed
pubmed-article:1309795pubmed:authorpubmed-author:VanceD EDElld:pubmed
pubmed-article:1309795pubmed:authorpubmed-author:JamilHHlld:pubmed
pubmed-article:1309795pubmed:authorpubmed-author:UtalA KAKlld:pubmed
pubmed-article:1309795pubmed:issnTypePrintlld:pubmed
pubmed-article:1309795pubmed:day25lld:pubmed
pubmed-article:1309795pubmed:volume267lld:pubmed
pubmed-article:1309795pubmed:ownerNLMlld:pubmed
pubmed-article:1309795pubmed:authorsCompleteYlld:pubmed
pubmed-article:1309795pubmed:pagination1752-60lld:pubmed
pubmed-article:1309795pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:meshHeadingpubmed-meshheading:1309795-...lld:pubmed
pubmed-article:1309795pubmed:year1992lld:pubmed
pubmed-article:1309795pubmed:articleTitleEvidence that cyclic AMP-induced inhibition of phosphatidylcholine biosynthesis is caused by a decrease in cellular diacylglycerol levels in cultured rat hepatocytes.lld:pubmed
pubmed-article:1309795pubmed:affiliationLipid and Lipoprotein Research Group, University of Alberta, Edmonton, Canada.lld:pubmed
pubmed-article:1309795pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1309795pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1309795lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1309795lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1309795lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1309795lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1309795lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1309795lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1309795lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1309795lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1309795lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1309795lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1309795lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1309795lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1309795lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1309795lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1309795lld:pubmed