| pubmed-article:12975347 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12975347 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:12975347 | lifeskim:mentions | umls-concept:C1427590 | lld:lifeskim |
| pubmed-article:12975347 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:12975347 | lifeskim:mentions | umls-concept:C0597452 | lld:lifeskim |
| pubmed-article:12975347 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:12975347 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:12975347 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:12975347 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:12975347 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12975347 | pubmed:dateCreated | 2003-9-16 | lld:pubmed |
| pubmed-article:12975347 | pubmed:abstractText | We examined the temporal and causal relationship between Smac/DIABLO release, cytochrome c (cyt-c) release, and caspase activation at the single cell level during apoptosis. Cells treated with the broad-spectrum caspase inhibitor z-VAD-fmk, caspase-3 (Casp-3)-deficient MCF-7 cells, as well as Bax-deficient DU-145 cells released Smac/DIABLO and cyt-c in response to proapoptotic agents. Real-time confocal imaging of MCF-7 cells stably expressing Smac/DIABLO-yellow fluorescent protein (YFP) revealed that the average duration of Smac/DIABLO-YFP release was greater than that of cyt-c-green fluorescent protein (GFP). However, there was no significant difference in the time to the onset of release, and both cyt-c-GFP and Smac/DIABLO-YFP release coincided with mitochondrial membrane potential depolarization. We also observed no significant differences in the Smac/DIABLO-YFP release kinetics when z-VAD-fmk-sensitive caspases were inhibited or Casp-3 was reintroduced. Simultaneous measurement of DEVDase activation and Smac/DIABLO-YFP release demonstrated that DEVDase activation occurred within 10 min of release, even in the absence of Casp-3. | lld:pubmed |
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| pubmed-article:12975347 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12975347 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12975347 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12975347 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12975347 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:12975347 | pubmed:author | pubmed-author:DüssmannHeiko... | lld:pubmed |
| pubmed-article:12975347 | pubmed:author | pubmed-author:PrehnJochen... | lld:pubmed |
| pubmed-article:12975347 | pubmed:author | pubmed-author:RehmMarkusM | lld:pubmed |
| pubmed-article:12975347 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12975347 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12975347 | pubmed:volume | 162 | lld:pubmed |
| pubmed-article:12975347 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12975347 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12975347 | pubmed:pagination | 1031-43 | lld:pubmed |
| pubmed-article:12975347 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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