Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12968005rdf:typepubmed:Citationlld:pubmed
pubmed-article:12968005lifeskim:mentionsumls-concept:C0015576lld:lifeskim
pubmed-article:12968005lifeskim:mentionsumls-concept:C0027793lld:lifeskim
pubmed-article:12968005lifeskim:mentionsumls-concept:C0033684lld:lifeskim
pubmed-article:12968005lifeskim:mentionsumls-concept:C0376515lld:lifeskim
pubmed-article:12968005lifeskim:mentionsumls-concept:C1332397lld:lifeskim
pubmed-article:12968005lifeskim:mentionsumls-concept:C1709059lld:lifeskim
pubmed-article:12968005pubmed:issue23lld:pubmed
pubmed-article:12968005pubmed:dateCreated2003-9-11lld:pubmed
pubmed-article:12968005pubmed:abstractTextBCL-2 family proteins are known to regulate cell death during development by influencing the permeability of mitochondrial membranes. The anti-apoptotic BCL-2 family protein BCL-xL is highly expressed in the adult brain and localizes to mitochondria in the presynaptic terminal of the adult squid stellate ganglion. Application of recombinant BCL-xL through a patch pipette to mitochondria inside the giant presynaptic terminal triggered multiconductance channel activity in mitochondrial membranes. Furthermore, injection of full-length BCL-xL protein into the presynaptic terminal enhanced postsynaptic responses and enhanced the rate of recovery from synaptic depression, whereas a recombinant pro-apoptotic cleavage product of BCL-xL attenuated postsynaptic responses. The effect of BCL-xL on synaptic responses persisted in the presence of a blocker of mitochondrial calcium uptake and was mimicked by injection of ATP into the terminal. These studies indicate that the permeability of outer mitochondrial membranes influences synaptic transmission, and they raise the possibility that modulation of mitochondrial conductance by BCL-2 family proteins affects synaptic stability.lld:pubmed
pubmed-article:12968005pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12968005pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12968005pubmed:languageenglld:pubmed
pubmed-article:12968005pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12968005pubmed:citationSubsetIMlld:pubmed
pubmed-article:12968005pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12968005pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12968005pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12968005pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12968005pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12968005pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12968005pubmed:statusMEDLINElld:pubmed
pubmed-article:12968005pubmed:monthSeplld:pubmed
pubmed-article:12968005pubmed:issn1529-2401lld:pubmed
pubmed-article:12968005pubmed:authorpubmed-author:KaczmarekLeon...lld:pubmed
pubmed-article:12968005pubmed:authorpubmed-author:HickmanJohn...lld:pubmed
pubmed-article:12968005pubmed:authorpubmed-author:HardwickJ...lld:pubmed
pubmed-article:12968005pubmed:authorpubmed-author:PolsterBrian...lld:pubmed
pubmed-article:12968005pubmed:authorpubmed-author:FannjiangYihr...lld:pubmed
pubmed-article:12968005pubmed:authorpubmed-author:JonasElizabet...lld:pubmed
pubmed-article:12968005pubmed:authorpubmed-author:HoitDanielDlld:pubmed
pubmed-article:12968005pubmed:authorpubmed-author:BrandtTeresa...lld:pubmed
pubmed-article:12968005pubmed:authorpubmed-author:McCarthyErinElld:pubmed
pubmed-article:12968005pubmed:authorpubmed-author:MontanezMarle...lld:pubmed
pubmed-article:12968005pubmed:issnTypeElectroniclld:pubmed
pubmed-article:12968005pubmed:day10lld:pubmed
pubmed-article:12968005pubmed:volume23lld:pubmed
pubmed-article:12968005pubmed:ownerNLMlld:pubmed
pubmed-article:12968005pubmed:authorsCompleteYlld:pubmed
pubmed-article:12968005pubmed:pagination8423-31lld:pubmed
pubmed-article:12968005pubmed:dateRevised2007-11-15lld:pubmed
pubmed-article:12968005pubmed:meshHeadingpubmed-meshheading:12968005...lld:pubmed
pubmed-article:12968005pubmed:meshHeadingpubmed-meshheading:12968005...lld:pubmed
pubmed-article:12968005pubmed:meshHeadingpubmed-meshheading:12968005...lld:pubmed
pubmed-article:12968005pubmed:meshHeadingpubmed-meshheading:12968005...lld:pubmed
pubmed-article:12968005pubmed:meshHeadingpubmed-meshheading:12968005...lld:pubmed
pubmed-article:12968005pubmed:meshHeadingpubmed-meshheading:12968005...lld:pubmed
pubmed-article:12968005pubmed:meshHeadingpubmed-meshheading:12968005...lld:pubmed
pubmed-article:12968005pubmed:meshHeadingpubmed-meshheading:12968005...lld:pubmed
pubmed-article:12968005pubmed:meshHeadingpubmed-meshheading:12968005...lld:pubmed
pubmed-article:12968005pubmed:meshHeadingpubmed-meshheading:12968005...lld:pubmed
pubmed-article:12968005pubmed:meshHeadingpubmed-meshheading:12968005...lld:pubmed
pubmed-article:12968005pubmed:meshHeadingpubmed-meshheading:12968005...lld:pubmed
pubmed-article:12968005pubmed:meshHeadingpubmed-meshheading:12968005...lld:pubmed
pubmed-article:12968005pubmed:meshHeadingpubmed-meshheading:12968005...lld:pubmed
pubmed-article:12968005pubmed:year2003lld:pubmed
pubmed-article:12968005pubmed:articleTitleModulation of synaptic transmission by the BCL-2 family protein BCL-xL.lld:pubmed
pubmed-article:12968005pubmed:affiliationDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06250, USA.lld:pubmed
pubmed-article:12968005pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12968005pubmed:publicationTypeIn Vitrolld:pubmed
pubmed-article:12968005pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:12968005pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12968005lld:pubmed