| pubmed-article:12967479 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12967479 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:12967479 | lifeskim:mentions | umls-concept:C0024623 | lld:lifeskim |
| pubmed-article:12967479 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:12967479 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:12967479 | lifeskim:mentions | umls-concept:C0042196 | lld:lifeskim |
| pubmed-article:12967479 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12967479 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12967479 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:12967479 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12967479 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12967479 | lifeskim:mentions | umls-concept:C0205470 | lld:lifeskim |
| pubmed-article:12967479 | lifeskim:mentions | umls-concept:C1705938 | lld:lifeskim |
| pubmed-article:12967479 | lifeskim:mentions | umls-concept:C2347662 | lld:lifeskim |
| pubmed-article:12967479 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:12967479 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12967479 | pubmed:dateCreated | 2003-9-11 | lld:pubmed |
| pubmed-article:12967479 | pubmed:abstractText | There is no standard treatment modality for advanced gastric cancer (GC) at the present time. To develop a new treatment modality, we investigated the immunological responses of advanced GC patients (n = 13, 9 non-scirrhous and 4 scirrhous types) vaccinated with peptides to a regimen under which pre-vaccination peripheral blood mononuclear cells (PBMCs) were screened for their reactivity in vitro to each of 14 peptides on HLA-A24 or 16 peptides on -A2 allele, then only the reactive peptides (maximum: 4) were administered in vivo. This regimen was generally well tolerated, although grade I levels of fever and local skin reactions were observed in several patients. Delayed-type hypersensitivity (DTH) to the vaccinated peptides was observed in 4 patients. Increased cellular and humoral immune responses to the vaccinated peptides were observed in post-vaccination PBMCs from 4 of 8 patients and in post-vaccination sera of 8 of 10 patients tested, respectively. Prolonged survival was observed in patients showing cellular and humoral immune responses to the vaccinated peptides in the post-vaccination samples, including all 4 patients with the scirrhous type. These results encourage further development of peptide-based immunotherapy for GC patients. | lld:pubmed |
| pubmed-article:12967479 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12967479 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12967479 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12967479 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12967479 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12967479 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12967479 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12967479 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12967479 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12967479 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12967479 | pubmed:issn | 1347-9032 | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:YamadaAkiraA | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:SatoMikaM | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:TodoSatoruS | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:ItohKyogoK | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:MaedaYoshiaki... | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:MineTakashiT | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:KondoMasaoM | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:YamanaHideaki... | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:KatagiriKazuk... | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:SatoYujiY | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:ShomuraHiroki... | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:UneYoshieY | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:AkasakaYoshin... | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:TakahashiShus... | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:ShinoharaTosh... | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:OkadaShioriS | lld:pubmed |
| pubmed-article:12967479 | pubmed:author | pubmed-author:MatsuiKanaeK | lld:pubmed |
| pubmed-article:12967479 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12967479 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:12967479 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12967479 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12967479 | pubmed:pagination | 802-8 | lld:pubmed |
| pubmed-article:12967479 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:12967479 | pubmed:meshHeading | pubmed-meshheading:12967479... | lld:pubmed |
| pubmed-article:12967479 | pubmed:meshHeading | pubmed-meshheading:12967479... | lld:pubmed |
| pubmed-article:12967479 | pubmed:meshHeading | pubmed-meshheading:12967479... | lld:pubmed |
| pubmed-article:12967479 | pubmed:meshHeading | pubmed-meshheading:12967479... | lld:pubmed |
| pubmed-article:12967479 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12967479 | pubmed:articleTitle | Immunological evaluation of peptide vaccination for patients with gastric cancer based on pre-existing cellular response to peptide. | lld:pubmed |
| pubmed-article:12967479 | pubmed:affiliation | First Department of Surgery, Hokkaido University School of Medicine, N15 W7 Sapporo, Hokkaido 060-8638, Japan. | lld:pubmed |
| pubmed-article:12967479 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12967479 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:12967479 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12967479 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:12967479 | pubmed:publicationType | Clinical Trial, Phase I | lld:pubmed |
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