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pubmed-article:12966327pubmed:abstractTextExposure to ethanol (EtOH) can be deleterious to the developing central nervous system. The mechanisms by which EtOH exposure induces neural pathology in utero remain unclear. However, EtOH-induced increases in protein kinase C (PKC) have been associated with apoptosis in human primary cell cultures. Although the toxic effects of EtOH on differentiated neural cells have been studied in laboratory animal models, the susceptibility of the human neural stem cells (NSCs) that predominate in the central nervous system during embryonic development has not been addressed.lld:pubmed
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pubmed-article:12966327pubmed:authorpubmed-author:ZhaoJaneJlld:pubmed
pubmed-article:12966327pubmed:authorpubmed-author:HaoHsiao-NanH...lld:pubmed
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pubmed-article:12966327pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12966327pubmed:articleTitleHuman neural stem cells are more sensitive than astrocytes to ethanol exposure.lld:pubmed
pubmed-article:12966327pubmed:affiliationDepartment of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA. hsiao-nan.hao@crcm.med.wayne.edulld:pubmed
pubmed-article:12966327pubmed:publicationTypeJournal Articlelld:pubmed
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