| pubmed-article:12949232 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12949232 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:12949232 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12949232 | lifeskim:mentions | umls-concept:C1176472 | lld:lifeskim |
| pubmed-article:12949232 | lifeskim:mentions | umls-concept:C0206441 | lld:lifeskim |
| pubmed-article:12949232 | lifeskim:mentions | umls-concept:C0934502 | lld:lifeskim |
| pubmed-article:12949232 | lifeskim:mentions | umls-concept:C2348043 | lld:lifeskim |
| pubmed-article:12949232 | lifeskim:mentions | umls-concept:C1552933 | lld:lifeskim |
| pubmed-article:12949232 | lifeskim:mentions | umls-concept:C2700485 | lld:lifeskim |
| pubmed-article:12949232 | lifeskim:mentions | umls-concept:C1521738 | lld:lifeskim |
| pubmed-article:12949232 | pubmed:issue | Pt 1 | lld:pubmed |
| pubmed-article:12949232 | pubmed:dateCreated | 2003-11-17 | lld:pubmed |
| pubmed-article:12949232 | pubmed:abstractText | Whole-cell voltage recordings were made in vivo from subsequently reconstructed pyramidal neurons (n = 30) in layer 3 (L3) and layer 2 (L2) of the barrel cortex of urethane-anaesthetised rats. Average resting membrane potentials were well below (15-40 mV) action potential (AP) initiation threshold. The average spontaneous AP activity (0.068 +/- 0.22 APs s-1) was low. Principal whisker (PW) deflections evoked postsynaptic potentials (PSPs) in almost all cells of a PW column but evoked AP activity (0.031 +/- 0.056 APs per PW stimulus 6 deg deflection) was low indicating 'sparse' coding by APs. Barrel-related cells (n = 16) have their soma located above a barrel and project their main axon through the barrel whereas septum-related cells (n = 8) are located above and project their main axon through the septum between barrels. Both classes of cell had broad subthreshold receptive fields (RFs) which comprised a PW and several (> 8) surround whiskers (SuW). Barrel-related cells had shorter PSP onset latencies (9.6 +/- 4.6 ms) and larger amplitude PW stimulus responses (9.1 +/- 4.5 mV) than septum-related cells (23.3 +/- 16.5 ms and 5.0 +/- 2.8 mV, respectively). The dendritic fields of barrel-related cells were restricted, in the horizontal plane, to the PW column width. Their axonal arbors projected horizontally into several SuW columns, preferentially those representing whiskers of the same row, suggesting that they are the major anatomical substrate for the broad subthreshold RFs. In barrel-related cells the response time course varied with whisker position and subthreshold RFs were highly dynamic, expanding in size from narrow single-whisker to broad multi-whisker RFs, elongated along rows within 10-150 ms following a deflection. The response time course in septum-related cells was much longer and almost independent of whisker position. Their broad subthreshold RF suggests that L2/3 cells integrate PSPs from several barrel columns. We conclude that the lemniscal (barrel-related) and paralemniscal (septum-related) afferent inputs remain anatomically and functionally segregated in L2/3. | lld:pubmed |
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| pubmed-article:12949232 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12949232 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12949232 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12949232 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12949232 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12949232 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:12949232 | pubmed:author | pubmed-author:BrechtMichael... | lld:pubmed |
| pubmed-article:12949232 | pubmed:author | pubmed-author:SakmannBertB | lld:pubmed |
| pubmed-article:12949232 | pubmed:author | pubmed-author:RothArndA | lld:pubmed |
| pubmed-article:12949232 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12949232 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12949232 | pubmed:volume | 553 | lld:pubmed |
| pubmed-article:12949232 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12949232 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12949232 | pubmed:pagination | 243-65 | lld:pubmed |
| pubmed-article:12949232 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12949232 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12949232 | pubmed:articleTitle | Dynamic receptive fields of reconstructed pyramidal cells in layers 3 and 2 of rat somatosensory barrel cortex. | lld:pubmed |
| pubmed-article:12949232 | pubmed:affiliation | Department of Cell Physiology, Max-Planck Institute for Medical Research, Heidelberg, Germany. brecht@mpimf-heidelberg.de | lld:pubmed |
| pubmed-article:12949232 | pubmed:publicationType | Journal Article | lld:pubmed |
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