| pubmed-article:12933852 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12933852 | lifeskim:mentions | umls-concept:C0038411 | lld:lifeskim |
| pubmed-article:12933852 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:12933852 | lifeskim:mentions | umls-concept:C0449943 | lld:lifeskim |
| pubmed-article:12933852 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:12933852 | lifeskim:mentions | umls-concept:C0069559 | lld:lifeskim |
| pubmed-article:12933852 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12933852 | pubmed:dateCreated | 2003-8-22 | lld:pubmed |
| pubmed-article:12933852 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12933852 | pubmed:abstractText | Serum opacity factor (SOF) is a protein expressed by Streptococcus pyogenes that opacifies mammalian serum. SOF is also a virulence factor of S. pyogenes, but it has not been previously shown to elicit a protective immune response. Herein, we report that SOF evokes bactericidal antibodies against S. pyogenes in humans, rabbits, and mice. Rabbit antiserum against purified recombinant SOF2 opsonized SOF-positive M type 2, 4, and 28 S. pyogenes in human blood but had no effect on SOF-negative M type 5 S. pyogenes. Furthermore, affinity-purified human antibodies against SOF2 also opsonized SOF-positive streptococci. A combination of antisera against M2 and SOF2 proteins was dramatically more effective in killing streptococci than either antiserum alone, indicating that antibodies against SOF2 enhance the opsonic efficiency of M protein antibodies. Mice tolerated an intravenous injection of 100 microg of SOF without overt signs of toxicity, and immunization with SOF protected mice against challenge infections with M type 2 S. pyogenes. These data indicate that SOF evokes opsonic antibodies that may protect against infections by SOF-positive serotypes of group A streptococci and suggest that different serotypes of SOF have common epitopes that may be useful vaccine candidates to protect against group A streptococcal infections. | lld:pubmed |
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| pubmed-article:12933852 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12933852 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12933852 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12933852 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12933852 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12933852 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12933852 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:12933852 | pubmed:author | pubmed-author:HastyDavid... | lld:pubmed |
| pubmed-article:12933852 | pubmed:author | pubmed-author:DaleJames BJB | lld:pubmed |
| pubmed-article:12933852 | pubmed:author | pubmed-author:CourtneyHarry... | lld:pubmed |
| pubmed-article:12933852 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12933852 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:12933852 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12933852 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12933852 | pubmed:pagination | 5097-103 | lld:pubmed |
| pubmed-article:12933852 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12933852 | pubmed:meshHeading | pubmed-meshheading:12933852... | lld:pubmed |
| pubmed-article:12933852 | pubmed:meshHeading | pubmed-meshheading:12933852... | lld:pubmed |
| pubmed-article:12933852 | pubmed:meshHeading | pubmed-meshheading:12933852... | lld:pubmed |
| pubmed-article:12933852 | pubmed:meshHeading | pubmed-meshheading:12933852... | lld:pubmed |
| pubmed-article:12933852 | pubmed:meshHeading | pubmed-meshheading:12933852... | lld:pubmed |
| pubmed-article:12933852 | pubmed:meshHeading | pubmed-meshheading:12933852... | lld:pubmed |
| pubmed-article:12933852 | pubmed:meshHeading | pubmed-meshheading:12933852... | lld:pubmed |
| pubmed-article:12933852 | pubmed:meshHeading | pubmed-meshheading:12933852... | lld:pubmed |
| pubmed-article:12933852 | pubmed:meshHeading | pubmed-meshheading:12933852... | lld:pubmed |
| pubmed-article:12933852 | pubmed:meshHeading | pubmed-meshheading:12933852... | lld:pubmed |
| pubmed-article:12933852 | pubmed:meshHeading | pubmed-meshheading:12933852... | lld:pubmed |
| pubmed-article:12933852 | pubmed:meshHeading | pubmed-meshheading:12933852... | lld:pubmed |
| pubmed-article:12933852 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12933852 | pubmed:articleTitle | Serum opacity factor (SOF) of Streptococcus pyogenes evokes antibodies that opsonize homologous and heterologous SOF-positive serotypes of group A streptococci. | lld:pubmed |
| pubmed-article:12933852 | pubmed:affiliation | Veterans Affairs Medical Center and Department of Medicine, University of Tennessee, Memphis, Tennessee 38104, USA. hcourtney@utmem.edu | lld:pubmed |
| pubmed-article:12933852 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12933852 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12933852 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12933852 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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