| pubmed-article:12932351 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12932351 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12932351 | lifeskim:mentions | umls-concept:C1515432 | lld:lifeskim |
| pubmed-article:12932351 | lifeskim:mentions | umls-concept:C1167087 | lld:lifeskim |
| pubmed-article:12932351 | lifeskim:mentions | umls-concept:C1333030 | lld:lifeskim |
| pubmed-article:12932351 | lifeskim:mentions | umls-concept:C0001473 | lld:lifeskim |
| pubmed-article:12932351 | lifeskim:mentions | umls-concept:C1424954 | lld:lifeskim |
| pubmed-article:12932351 | lifeskim:mentions | umls-concept:C1705294 | lld:lifeskim |
| pubmed-article:12932351 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:12932351 | lifeskim:mentions | umls-concept:C0950301 | lld:lifeskim |
| pubmed-article:12932351 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12932351 | pubmed:dateCreated | 2003-8-22 | lld:pubmed |
| pubmed-article:12932351 | pubmed:abstractText | T cells develop through distinct stages directed by a series of signals. We explored the roles of SWI/SNF-like BAF chromatin remodeling complexes in this process by progressive deletion of the ATPase subunit, Brg, through successive stages of early T cell development. Brg-deficient cells were blocked at each of the developmental transitions examined. Bcl-xL overexpression suppressed cell death without relieving the developmental blockades, leading to the accumulation of Brg-deleted cells that were unexpectedly cell cycle arrested. These defects resulted partly from the disruptions of pre-TCR and potentially Wnt signaling pathways controlling the expression of genes such as c-Kit and c-Myc critical for continued development. Our studies indicate that BAF complexes dynamically remodel chromatin to propel sequential developmental transitions in response to external signals. | lld:pubmed |
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| pubmed-article:12932351 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12932351 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12932351 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12932351 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12932351 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12932351 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:12932351 | pubmed:author | pubmed-author:NawaM TMT | lld:pubmed |
| pubmed-article:12932351 | pubmed:author | pubmed-author:ChambonPierre... | lld:pubmed |
| pubmed-article:12932351 | pubmed:author | pubmed-author:WilsonChristo... | lld:pubmed |
| pubmed-article:12932351 | pubmed:author | pubmed-author:CrabtreeGeral... | lld:pubmed |
| pubmed-article:12932351 | pubmed:author | pubmed-author:MetzgerDaniel... | lld:pubmed |
| pubmed-article:12932351 | pubmed:author | pubmed-author:AkashiKoichiK | lld:pubmed |
| pubmed-article:12932351 | pubmed:author | pubmed-author:ChiTian HTH | lld:pubmed |
| pubmed-article:12932351 | pubmed:author | pubmed-author:LeePeggy PPP | lld:pubmed |
| pubmed-article:12932351 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12932351 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:12932351 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12932351 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12932351 | pubmed:pagination | 169-82 | lld:pubmed |
| pubmed-article:12932351 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12932351 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12932351 | pubmed:articleTitle | Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. | lld:pubmed |
| pubmed-article:12932351 | pubmed:affiliation | Departments of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA. | lld:pubmed |
| pubmed-article:12932351 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12932351 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12932351 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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