| pubmed-article:12930375 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12930375 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:12930375 | lifeskim:mentions | umls-concept:C0272286 | lld:lifeskim |
| pubmed-article:12930375 | lifeskim:mentions | umls-concept:C0037995 | lld:lifeskim |
| pubmed-article:12930375 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:12930375 | lifeskim:mentions | umls-concept:C1880371 | lld:lifeskim |
| pubmed-article:12930375 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12930375 | pubmed:dateCreated | 2003-8-21 | lld:pubmed |
| pubmed-article:12930375 | pubmed:abstractText | In recent years, a pathophysiological role for T cells in immune thrombocytopenia (ITP) has been established. We applied cDNA size distribution analysis of the T cell receptor (TCR) beta-variable (VB) complementarity-determining region 3 (CDR3) in order to investigate T cell repertoire diversity among immune thrombocytopenia patients who had either responded or not responded to splenectomy, and compared them to normal controls. ITP patients who had had a durable platelet response to splenectomy showed a mean 2.8 +/- 2.1 abnormal CDR3 size patterns per patient, similar to healthy volunteers (2.9 +/- 2.0 abnormal CDR3 size patterns). In contrast, patients unresponsive to splenectomy demonstrated evidence of significantly more clonal T cell expansions than patients who had responded to splenectomy or controls (11.3 +/- 3.3 abnormal CDR3 size patterns per patient; P < 0.001). Of the VB subfamilies analysed, VB3 and VB15 correlated with response or non-response to splenectomy, each demonstrating oligoclonality in non-responding patients (P < 0.05). These findings suggest that removal of the spleen may lead directly or indirectly to reductions in T cell clonal expansions in responders, or that the extent of T cell clonality impacts responsiveness to splenectomy in patients with ITP. | lld:pubmed |
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| pubmed-article:12930375 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12930375 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12930375 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12930375 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12930375 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12930375 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:12930375 | pubmed:author | pubmed-author:ReedR MRM | lld:pubmed |
| pubmed-article:12930375 | pubmed:author | pubmed-author:ZengWW | lld:pubmed |
| pubmed-article:12930375 | pubmed:author | pubmed-author:BusselJ BJB | lld:pubmed |
| pubmed-article:12930375 | pubmed:author | pubmed-author:DunbarC ECE | lld:pubmed |
| pubmed-article:12930375 | pubmed:author | pubmed-author:FogartyP FPF | lld:pubmed |
| pubmed-article:12930375 | pubmed:author | pubmed-author:RisitanoA MAM | lld:pubmed |
| pubmed-article:12930375 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12930375 | pubmed:volume | 133 | lld:pubmed |
| pubmed-article:12930375 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12930375 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12930375 | pubmed:pagination | 461-6 | lld:pubmed |
| pubmed-article:12930375 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12930375 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12930375 | pubmed:articleTitle | T cell receptor VB repertoire diversity in patients with immune thrombocytopenia following splenectomy. | lld:pubmed |
| pubmed-article:12930375 | pubmed:affiliation | Hematology Section, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1652, USA. | lld:pubmed |
| pubmed-article:12930375 | pubmed:publicationType | Journal Article | lld:pubmed |
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