| pubmed-article:1292629 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1292629 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:1292629 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1292629 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:1292629 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:1292629 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:1292629 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:1292629 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1292629 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:1292629 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1292629 | pubmed:dateCreated | 1993-4-8 | lld:pubmed |
| pubmed-article:1292629 | pubmed:abstractText | Interferon gamma (IFN-gamma) production has been attributed exclusively to activated T cells and NK cells. We sought to determine whether human B cells express IFN-gamma. We studied 28 B cell lines including Epstein-Barr virus (EBV)+ normal lymphoblastoid B cell lines (N = 7), EBV+ B cell lines derived from patients with Burkitt's lymphoma with (N = 6) or without AIDS (N = 8), as well as seven EBV- B cell lines. All cell lines were studied by reverse transcription-polymerase chain reaction (RT-PCR). We detected constitutive expression of IFN-gamma in every B cell line. The tumor promoters PMA and teleocidin appeared to enhance this IFN-gamma expression in nearly every B cell line. The 517 bp amplicons spanning the entire protein coding region of the IFN-gamma mRNA from three representative lines were sequenced, definitively establishing that B cell IFN-gamma is identical to IFN-gamma from activated T cells and is not altered by derivation of the B cell lines from AIDS patients or by EBV status. Detection of IFN-gamma in the entire panel of EBV+ and EBV- cell lines suggests that the IFN-gamma gene is broadly expressed by human B cells. Our data imply that human B cells can be activated to produce IFN-gamma, further enmeshing B cells in the dynamics of immunoregulation. | lld:pubmed |
| pubmed-article:1292629 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1292629 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1292629 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1292629 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1292629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1292629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1292629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1292629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1292629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1292629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1292629 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1292629 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1292629 | pubmed:issn | 1043-4666 | lld:pubmed |
| pubmed-article:1292629 | pubmed:author | pubmed-author:BenjaminDD | lld:pubmed |
| pubmed-article:1292629 | pubmed:author | pubmed-author:DaytonM AMA | lld:pubmed |
| pubmed-article:1292629 | pubmed:author | pubmed-author:KnoblochT JTJ | lld:pubmed |
| pubmed-article:1292629 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1292629 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:1292629 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1292629 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1292629 | pubmed:pagination | 454-60 | lld:pubmed |
| pubmed-article:1292629 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:1292629 | pubmed:meshHeading | pubmed-meshheading:1292629-... | lld:pubmed |
| pubmed-article:1292629 | pubmed:meshHeading | pubmed-meshheading:1292629-... | lld:pubmed |
| pubmed-article:1292629 | pubmed:meshHeading | pubmed-meshheading:1292629-... | lld:pubmed |
| pubmed-article:1292629 | pubmed:meshHeading | pubmed-meshheading:1292629-... | lld:pubmed |
| pubmed-article:1292629 | pubmed:meshHeading | pubmed-meshheading:1292629-... | lld:pubmed |
| pubmed-article:1292629 | pubmed:meshHeading | pubmed-meshheading:1292629-... | lld:pubmed |
| pubmed-article:1292629 | pubmed:meshHeading | pubmed-meshheading:1292629-... | lld:pubmed |
| pubmed-article:1292629 | pubmed:meshHeading | pubmed-meshheading:1292629-... | lld:pubmed |
| pubmed-article:1292629 | pubmed:meshHeading | pubmed-meshheading:1292629-... | lld:pubmed |
| pubmed-article:1292629 | pubmed:meshHeading | pubmed-meshheading:1292629-... | lld:pubmed |
| pubmed-article:1292629 | pubmed:meshHeading | pubmed-meshheading:1292629-... | lld:pubmed |
| pubmed-article:1292629 | pubmed:meshHeading | pubmed-meshheading:1292629-... | lld:pubmed |
| pubmed-article:1292629 | pubmed:meshHeading | pubmed-meshheading:1292629-... | lld:pubmed |
| pubmed-article:1292629 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1292629 | pubmed:articleTitle | Human B cell lines express the interferon gamma gene. | lld:pubmed |
| pubmed-article:1292629 | pubmed:affiliation | Department of Internal Medicine, Ohio State University Comprehensive Cancer Center/Arthur G. James Cancer Hospital and Research Institute, Columbus 43210. | lld:pubmed |
| pubmed-article:1292629 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1292629 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1292629 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1292629 | lld:pubmed |
