Linked Life Data

12907425

Source:http://linkedlifedata.com/resource/pubmed/id/12907425

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12907425rdf:typepubmed:Citationlld:pubmed
pubmed-article:12907425lifeskim:mentionsumls-concept:C0026809lld:lifeskim
pubmed-article:12907425lifeskim:mentionsumls-concept:C0018787lld:lifeskim
pubmed-article:12907425lifeskim:mentionsumls-concept:C2709248lld:lifeskim
pubmed-article:12907425lifeskim:mentionsumls-concept:C0019010lld:lifeskim
pubmed-article:12907425lifeskim:mentionsumls-concept:C0376525lld:lifeskim
pubmed-article:12907425lifeskim:mentionsumls-concept:C0277785lld:lifeskim
pubmed-article:12907425lifeskim:mentionsumls-concept:C1999216lld:lifeskim
pubmed-article:12907425lifeskim:mentionsumls-concept:C1518425lld:lifeskim
pubmed-article:12907425lifeskim:mentionsumls-concept:C0205263lld:lifeskim
pubmed-article:12907425lifeskim:mentionsumls-concept:C0205373lld:lifeskim
pubmed-article:12907425lifeskim:mentionsumls-concept:C1292733lld:lifeskim
pubmed-article:12907425pubmed:issue6lld:pubmed
pubmed-article:12907425pubmed:dateCreated2003-11-17lld:pubmed
pubmed-article:12907425pubmed:abstractTextIncreased nitric oxide (NO) production by inducible NO synthase (NOS2), an obligate homodimer, is implicated in the cardiovascular sequelae of sepsis. We tested the ability of a highly selective NOS2 dimerization inhibitor (BBS-2) to prevent endotoxin-induced systemic hypotension, myocardial dysfunction, and impaired hypoxic pulmonary vasoconstriction (HPV) in mice. Mice were challenged with Escherichia coli endotoxin before treatment with BBS-2 or vehicle. Systemic blood pressure was measured before and 4 and 7 h after endotoxin challenge, and echocardiographic parameters of myocardial function were measured before and 7 h after endotoxin challenge. The pulmonary vasoconstrictor response to left mainstem bronchus occlusion, which is a measure of HPV, was studied 22 h after endotoxin challenge. BBS-2 treatment alone did not alter baseline hemodynamics. BBS-2 treatment blocked NOS2 dimerization and completely inhibited the endotoxin-induced increase of plasma nitrate and nitrite levels. Treatment with BBS-2 after endotoxin administration prevented systemic hypotension and attenuated myocardial dysfunction. BBS-2 also prevented endotoxin-induced impairment of HPV. In contrast, treatment with NG-nitro-l-arginine methyl ester, which is an inhibitor of all three NOS isoforms, prevented the systemic hypotension but further aggravated the myocardial dysfunction associated with endotoxin challenge. Treatment with BBS-2 prevented endotoxin from causing key features of cardiovascular dysfunction in endotoxemic mice. Selective inhibition of NOS2 dimerization with BBS-2, while sparing the activities of other NOS isoforms, may prove to be a useful treatment strategy in sepsis.lld:pubmed
pubmed-article:12907425pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12907425pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12907425pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12907425pubmed:languageenglld:pubmed
pubmed-article:12907425pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12907425pubmed:citationSubsetIMlld:pubmed
pubmed-article:12907425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12907425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12907425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12907425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12907425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12907425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12907425pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12907425pubmed:statusMEDLINElld:pubmed
pubmed-article:12907425pubmed:monthDeclld:pubmed
pubmed-article:12907425pubmed:issn0363-6135lld:pubmed
pubmed-article:12907425pubmed:authorpubmed-author:ParkinsonJohn...lld:pubmed
pubmed-article:12907425pubmed:authorpubmed-author:PicardMichael...lld:pubmed
pubmed-article:12907425pubmed:authorpubmed-author:WuJustina CJClld:pubmed
pubmed-article:12907425pubmed:authorpubmed-author:IchinoseFumit...lld:pubmed
pubmed-article:12907425pubmed:authorpubmed-author:BlochKenneth...lld:pubmed
pubmed-article:12907425pubmed:authorpubmed-author:ZapolWarren...lld:pubmed
pubmed-article:12907425pubmed:authorpubmed-author:KawaiNorikoNlld:pubmed
pubmed-article:12907425pubmed:authorpubmed-author:HataishiRyuji...lld:pubmed
pubmed-article:12907425pubmed:authorpubmed-author:RodriguesAna...lld:pubmed
pubmed-article:12907425pubmed:authorpubmed-author:MallariCornel...lld:pubmed
pubmed-article:12907425pubmed:authorpubmed-author:PostJoe MJMlld:pubmed
pubmed-article:12907425pubmed:issnTypePrintlld:pubmed
pubmed-article:12907425pubmed:volume285lld:pubmed
pubmed-article:12907425pubmed:ownerNLMlld:pubmed
pubmed-article:12907425pubmed:authorsCompleteYlld:pubmed
pubmed-article:12907425pubmed:paginationH2524-30lld:pubmed
pubmed-article:12907425pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:meshHeadingpubmed-meshheading:12907425...lld:pubmed
pubmed-article:12907425pubmed:year2003lld:pubmed
pubmed-article:12907425pubmed:articleTitleA selective inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice.lld:pubmed
pubmed-article:12907425pubmed:affiliationDepartment of Anesthesia and Critical Care and Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114-2620, USA. ichinose@etherdome.mgh.harvard.edulld:pubmed
pubmed-article:12907425pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12907425pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12907425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12907425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12907425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12907425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12907425lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12907425lld:pubmed