| pubmed-article:12902314 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12902314 | lifeskim:mentions | umls-concept:C0751964 | lld:lifeskim |
| pubmed-article:12902314 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:12902314 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:12902314 | pubmed:issue | Pt 11 | lld:pubmed |
| pubmed-article:12902314 | pubmed:dateCreated | 2003-10-16 | lld:pubmed |
| pubmed-article:12902314 | pubmed:abstractText | Longitudinal imaging studies of primary progressive multiple sclerosis (PPMS) have shown significant changes in MR measures over 1 to 2 years. Correlation with clinical change over the same period has not been evident; we investigated the possibility that this is because the period of observation was insufficient for these associations to become apparent. Forty-one patients with PPMS were followed prospectively for 5 years. Patients had clinical [Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Functional Composite Measure (MSFC)] and MRI assessment (brain and spinal cord) at baseline, 1, 2 and 5 years. At 5 years, significant deterioration was seen in all clinical and MRI measures (P<0.01, P<0.001 respectively). Associations were seen between increase in EDSS score and decrease in cord area (r=0.31, P<0.05) and between increase in MSFC and both rate of ventricular enlargement (r=0.31, P<0.05) and increase in T2 load (r=0.31, P<0.05). The rates of change of MR measures were not associated with age or disease duration and were more consistent within than between patients. Longer duration of follow-up demonstrates modest associations between change in clinical and MR measures and provides new insights into the pattern of change within and between individuals with PPMS. | lld:pubmed |
| pubmed-article:12902314 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12902314 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12902314 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12902314 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12902314 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12902314 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12902314 | pubmed:issn | 0006-8950 | lld:pubmed |
| pubmed-article:12902314 | pubmed:author | pubmed-author:ThompsonA JAJ | lld:pubmed |
| pubmed-article:12902314 | pubmed:author | pubmed-author:MillerD HDH | lld:pubmed |
| pubmed-article:12902314 | pubmed:author | pubmed-author:StevensonV... | lld:pubmed |
| pubmed-article:12902314 | pubmed:author | pubmed-author:IngleG TGT | lld:pubmed |
| pubmed-article:12902314 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12902314 | pubmed:volume | 126 | lld:pubmed |
| pubmed-article:12902314 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12902314 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12902314 | pubmed:pagination | 2528-36 | lld:pubmed |
| pubmed-article:12902314 | pubmed:dateRevised | 2011-11-3 | lld:pubmed |
| pubmed-article:12902314 | pubmed:meshHeading | pubmed-meshheading:12902314... | lld:pubmed |
| pubmed-article:12902314 | pubmed:meshHeading | pubmed-meshheading:12902314... | lld:pubmed |
| pubmed-article:12902314 | pubmed:meshHeading | pubmed-meshheading:12902314... | lld:pubmed |
| pubmed-article:12902314 | pubmed:meshHeading | pubmed-meshheading:12902314... | lld:pubmed |
| pubmed-article:12902314 | pubmed:meshHeading | pubmed-meshheading:12902314... | lld:pubmed |
| pubmed-article:12902314 | pubmed:meshHeading | pubmed-meshheading:12902314... | lld:pubmed |
| pubmed-article:12902314 | pubmed:meshHeading | pubmed-meshheading:12902314... | lld:pubmed |
| pubmed-article:12902314 | pubmed:meshHeading | pubmed-meshheading:12902314... | lld:pubmed |
| pubmed-article:12902314 | pubmed:meshHeading | pubmed-meshheading:12902314... | lld:pubmed |
| pubmed-article:12902314 | pubmed:meshHeading | pubmed-meshheading:12902314... | lld:pubmed |
| pubmed-article:12902314 | pubmed:meshHeading | pubmed-meshheading:12902314... | lld:pubmed |
| pubmed-article:12902314 | pubmed:meshHeading | pubmed-meshheading:12902314... | lld:pubmed |
| pubmed-article:12902314 | pubmed:meshHeading | pubmed-meshheading:12902314... | lld:pubmed |
| pubmed-article:12902314 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12902314 | pubmed:articleTitle | Primary progressive multiple sclerosis: a 5-year clinical and MR study. | lld:pubmed |
| pubmed-article:12902314 | pubmed:affiliation | Institute of Neurology, Uuniversity College, London, UK. | lld:pubmed |
| pubmed-article:12902314 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12902314 | lld:pubmed |
