| pubmed-article:12900547 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12900547 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:12900547 | lifeskim:mentions | umls-concept:C0001038 | lld:lifeskim |
| pubmed-article:12900547 | lifeskim:mentions | umls-concept:C0678928 | lld:lifeskim |
| pubmed-article:12900547 | lifeskim:mentions | umls-concept:C0002085 | lld:lifeskim |
| pubmed-article:12900547 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:12900547 | lifeskim:mentions | umls-concept:C1156205 | lld:lifeskim |
| pubmed-article:12900547 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:12900547 | pubmed:issue | 1-4 | lld:pubmed |
| pubmed-article:12900547 | pubmed:dateCreated | 2003-8-5 | lld:pubmed |
| pubmed-article:12900547 | pubmed:abstractText | In female mammals, one of the two X chromosomes is inactivated to compensate for the difference in dosage of X-linked genes between males and females. X inactivation involves sequential alterations to the chromatin that ultimately lead to the transcriptional repression of genes on the X chromosome. Here, histone methylation and acetylation along X-linked genes are investigated by chromatin immunoprecipitation (ChIP) of adult fibroblast cell lines. At PGK1 and HPRT, chromatin on the active X chromosome reveals H3 lysine 4 methylation and acetylation of histones H3 and H4. These modifications are absent on the repressed allele, which is marked by H3 lysine 9 methylation. On the expressed allele of XIST (on the inactive X chromosome), we found that H3 acetylation is confined to the promoter, whereas H3 lysine 4 methylation and H4 acetylation are present along the entire gene. On the repressed XIST allele, in contrast, the promoter and gene exhibit H3 lysine 9 methylation. At only 1.5 kb upstream of the XIST gene, chromatin on the inactive X chromosome has strongly reduced levels of H4 acetylation and is marked by both H3 lysine 9 and H3 lysine 4 methylation. These data demonstrate that patterns of histone methylation and acetylation are distinct along and upstream of XIST and suggest that the inactive X chromatin configuration occurs at a region close to the 5' end of the gene. | lld:pubmed |
| pubmed-article:12900547 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12900547 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900547 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12900547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900547 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12900547 | pubmed:issn | 1424-859X | lld:pubmed |
| pubmed-article:12900547 | pubmed:author | pubmed-author:GotoYY | lld:pubmed |
| pubmed-article:12900547 | pubmed:author | pubmed-author:FeilRR | lld:pubmed |
| pubmed-article:12900547 | pubmed:author | pubmed-author:GomezMM | lld:pubmed |
| pubmed-article:12900547 | pubmed:author | pubmed-author:BrockdorffNN | lld:pubmed |
| pubmed-article:12900547 | pubmed:copyrightInfo | Copyright 2003 S. Karger AG, Basel | lld:pubmed |
| pubmed-article:12900547 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:12900547 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:12900547 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12900547 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12900547 | pubmed:pagination | 66-74 | lld:pubmed |
| pubmed-article:12900547 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12900547 | pubmed:meshHeading | pubmed-meshheading:12900547... | lld:pubmed |
| pubmed-article:12900547 | pubmed:meshHeading | pubmed-meshheading:12900547... | lld:pubmed |
| pubmed-article:12900547 | pubmed:meshHeading | pubmed-meshheading:12900547... | lld:pubmed |
| pubmed-article:12900547 | pubmed:meshHeading | pubmed-meshheading:12900547... | lld:pubmed |
| pubmed-article:12900547 | pubmed:meshHeading | pubmed-meshheading:12900547... | lld:pubmed |
| pubmed-article:12900547 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12900547 | pubmed:articleTitle | Differential patterns of histone methylation and acetylation distinguish active and repressed alleles at X-linked genes. | lld:pubmed |
| pubmed-article:12900547 | pubmed:affiliation | Institute of Molecular Genetics, CNRS, Montpellier, France. | lld:pubmed |
| pubmed-article:12900547 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12900547 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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