| pubmed-article:12885762 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12885762 | lifeskim:mentions | umls-concept:C0911469 | lld:lifeskim |
| pubmed-article:12885762 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12885762 | lifeskim:mentions | umls-concept:C1709694 | lld:lifeskim |
| pubmed-article:12885762 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12885762 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12885762 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12885762 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12885762 | pubmed:dateCreated | 2003-8-5 | lld:pubmed |
| pubmed-article:12885762 | pubmed:abstractText | Phylogenetic analysis clusters caspase-12 with the inflammatory caspases 1 and 11. We analyzed the expression of caspase-12 in mouse embryos, adult organs, and different cell types and tested the effect of interferons (IFNs) and other proinflammatory stimuli. Constitutive expression of the caspase-12 protein was restricted to certain cell types, such as epithelial cells, primary fibroblasts, and L929 fibrosarcoma cells. In fibroblasts and B16/B16 melanoma cells, caspase-12 expression is stimulated by IFN-gamma but not by IFN-alpha or -beta. The effect is increased further when IFN-gamma is combined with TNF, lipopolysaccharide (LPS), or dsRNA. These stimuli also induce caspase-1 and -11 but inhibit the expression of caspase-3 and -9. In contrast to caspase-1 and -11, no caspase-12 protein was detected in macrophages in any of these treatments. Transient overexpression of full-length caspase-12 leads to proteolytic processing of the enzyme and apoptosis. Similar processing occurs in TNF-, LPS-, Fas ligand-, and thapsigargin (Tg)-induced apoptosis. However, B16/B16 melanoma cells die when treated with the ER stress-inducing agent Tg whether they express caspase-12 or not. | lld:pubmed |
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| pubmed-article:12885762 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12885762 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12885762 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12885762 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12885762 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:12885762 | pubmed:author | pubmed-author:VandenabeeleP... | lld:pubmed |
| pubmed-article:12885762 | pubmed:author | pubmed-author:DeneckerGeert... | lld:pubmed |
| pubmed-article:12885762 | pubmed:author | pubmed-author:KalaiMichaelM | lld:pubmed |
| pubmed-article:12885762 | pubmed:author | pubmed-author:DeclercqWimW | lld:pubmed |
| pubmed-article:12885762 | pubmed:author | pubmed-author:LippensSaskia... | lld:pubmed |
| pubmed-article:12885762 | pubmed:author | pubmed-author:LamkanfiMoham... | lld:pubmed |
| pubmed-article:12885762 | pubmed:author | pubmed-author:BoogmansMicha... | lld:pubmed |
| pubmed-article:12885762 | pubmed:author | pubmed-author:MeeusAnnA | lld:pubmed |
| pubmed-article:12885762 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12885762 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:12885762 | pubmed:volume | 162 | lld:pubmed |
| pubmed-article:12885762 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12885762 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12885762 | pubmed:pagination | 457-67 | lld:pubmed |
| pubmed-article:12885762 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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