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pubmed-article:12882650pubmed:abstractTextAdoptive immunotherapy with cytotoxic T lymphocytes (CTL) represents an alternative approach to treating solid tumors. Ideally, this would confer long-term protection against tumor. We previously demonstrated that in vitro-generated tumor-specific CTL from the ovalbumin (OVA)-specific OT-I T cell receptor transgenic mouse persisted long after adoptive transfer as memory T cells. When recipient mice were challenged with the OVA-expressing E.G7 thymoma, tumor growth was delayed and sometimes prevented. The reasons for therapeutic failures were not clear.lld:pubmed
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pubmed-article:12882650pubmed:articleTitleTherapeutic limitations in tumor-specific CD8+ memory T cell engraftment.lld:pubmed
pubmed-article:12882650pubmed:affiliationDepartment of Surgery, University of Calgary, Calgary, AB, Canada. bathe@ucalgary.calld:pubmed
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