| pubmed-article:12871638 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12871638 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:12871638 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12871638 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:12871638 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:12871638 | lifeskim:mentions | umls-concept:C0020966 | lld:lifeskim |
| pubmed-article:12871638 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:12871638 | lifeskim:mentions | umls-concept:C1879746 | lld:lifeskim |
| pubmed-article:12871638 | lifeskim:mentions | umls-concept:C1547011 | lld:lifeskim |
| pubmed-article:12871638 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12871638 | pubmed:dateCreated | 2003-7-21 | lld:pubmed |
| pubmed-article:12871638 | pubmed:abstractText | Peptide:MHC II complexes derived from a fluorescent antigen were detected in vivo to identify the cells that present subcutaneously injected antigen to CD4 T cells. Skin-derived dendritic cells (DCs) that acquired the antigen while in the draining lymph nodes were the first cells to display peptide:MHC II complexes. Presentation by these cells induced CD69, IL-2 production, and maximal proliferation by the T cells. Later, DCs displaying peptide:MHC II complexes migrated from the injection site via a G protein-dependent mechanism. Presentation by these migrants sustained expression of the IL-2 receptor and promoted delayed type hypersensitivity. Therefore, presentation of peptide:MHC II complexes derived from a subcutaneous antigen occurs in two temporally distinct waves with different functional consequences. | lld:pubmed |
| pubmed-article:12871638 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12871638 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12871638 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12871638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12871638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12871638 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12871638 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12871638 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:12871638 | pubmed:author | pubmed-author:RudenskyAlexa... | lld:pubmed |
| pubmed-article:12871638 | pubmed:author | pubmed-author:McSorleySteph... | lld:pubmed |
| pubmed-article:12871638 | pubmed:author | pubmed-author:ReinhardtR... | lld:pubmed |
| pubmed-article:12871638 | pubmed:author | pubmed-author:JenkinsMarc... | lld:pubmed |
| pubmed-article:12871638 | pubmed:author | pubmed-author:IngulliElizab... | lld:pubmed |
| pubmed-article:12871638 | pubmed:author | pubmed-author:EhstBenjamin... | lld:pubmed |
| pubmed-article:12871638 | pubmed:author | pubmed-author:ItanoAndrea... | lld:pubmed |
| pubmed-article:12871638 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12871638 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:12871638 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12871638 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12871638 | pubmed:pagination | 47-57 | lld:pubmed |
| pubmed-article:12871638 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:12871638 | pubmed:meshHeading | pubmed-meshheading:12871638... | lld:pubmed |
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| pubmed-article:12871638 | pubmed:meshHeading | pubmed-meshheading:12871638... | lld:pubmed |
| pubmed-article:12871638 | pubmed:meshHeading | pubmed-meshheading:12871638... | lld:pubmed |
| pubmed-article:12871638 | pubmed:meshHeading | pubmed-meshheading:12871638... | lld:pubmed |
| pubmed-article:12871638 | pubmed:meshHeading | pubmed-meshheading:12871638... | lld:pubmed |
| pubmed-article:12871638 | pubmed:meshHeading | pubmed-meshheading:12871638... | lld:pubmed |
| pubmed-article:12871638 | pubmed:meshHeading | pubmed-meshheading:12871638... | lld:pubmed |
| pubmed-article:12871638 | pubmed:meshHeading | pubmed-meshheading:12871638... | lld:pubmed |
| pubmed-article:12871638 | pubmed:meshHeading | pubmed-meshheading:12871638... | lld:pubmed |
| pubmed-article:12871638 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12871638 | pubmed:articleTitle | Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. | lld:pubmed |
| pubmed-article:12871638 | pubmed:affiliation | Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. itano001@imn.edu | lld:pubmed |
| pubmed-article:12871638 | pubmed:publicationType | Journal Article | lld:pubmed |
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