Linked Life Data

12853136

Source:http://linkedlifedata.com/resource/pubmed/id/12853136

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pubmed-article:12853136pubmed:abstractTextEach prokaryote has a unique genomic signature as evidenced by a set of species-specific frequencies of short oligonucleotides. With respect to genomic signatures a bacterial genome is homogenous and the variation within a genome is smaller than the variations between genomes of different species. This study quantifies the species-specificity of genomic signatures in the complete genomes of 57 prokaryotes. The species-specificity in the genomic signature was related to the quantification of other sequence biases, such as G+C content, synonymous codon choice and amino acid usage. The results confirm that the genomic signature is genome-wide with high species-specificity in both coding and non-coding regions. In coding regions the species-specific bias in synonymous codon choice was comparable to the genomic signature, while the bias in amino acid usage only captured about 50% of the species-specific bias in the genomic signature. A correlation between the species-specificity in synonymous codon choice and amino acid usage was identified, in which proteins with species-specific amino acid usage were also coded with species-specific synonymous codon choice. However, we demonstrated that the G+C content captures only approximately 40% of the species-specificity in the genomic signature, and is insufficient to explain the species specificity in the non-coding regions. Thus, the species-specific bias in non-coding regions remains largely unknown. Further, we compared the genomic signature in relation to phylogenetic distance. This was performed in order to illustrate the feasibility of a hierarchical classification scheme in future applications of the described classification methodology in screening for horizontal gene transfer and biodiversity studies.lld:pubmed
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pubmed-article:12853136pubmed:authorpubmed-author:SandbergRicka...lld:pubmed
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pubmed-article:12853136pubmed:pagination35-42lld:pubmed
pubmed-article:12853136pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12853136pubmed:articleTitleQuantifying the species-specificity in genomic signatures, synonymous codon choice, amino acid usage and G+C content.lld:pubmed
pubmed-article:12853136pubmed:affiliationMicrobiology and Tumor Biology Center, Karolinska Institute, S-171 77 Stockholm, Sweden. Rickard.Sandberg@mtc.ki.selld:pubmed
pubmed-article:12853136pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12853136pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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