| pubmed-article:12823283 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12823283 | lifeskim:mentions | umls-concept:C0019342 | lld:lifeskim |
| pubmed-article:12823283 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:12823283 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:12823283 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:12823283 | lifeskim:mentions | umls-concept:C0699749 | lld:lifeskim |
| pubmed-article:12823283 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12823283 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:12823283 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12823283 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12823283 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12823283 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12823283 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12823283 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12823283 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12823283 | pubmed:dateCreated | 2003-6-25 | lld:pubmed |
| pubmed-article:12823283 | pubmed:abstractText | Cell-mediated T-helper type-1 (Th1) responses play a vital role in the immunopathogenesis of genital infections caused by herpes simplex virus 2 (HSV-2). We investigated the role of Th responses in HSV-2 infection at different disease stages by analysing the production of Th cytokines in HSV-stimulated peripheral blood mononuclear cells (PBMCs). IFN-gamma production decreased over time following a recurrence, whereas levels of IL-10, and to a lesser extent IL-2, remained elevated during this period. In addition, PBMCs from asymptomatic seropositive individuals produced high levels of IFN-gamma and low levels of IL-10, in contrast to individuals with a history of genital ulcers. Following a recurrence, virus copy number in the genital lesions decreased progressively over time, in a manner similar to IFN-gamma production by HSV-2-stimulated PBMCs. Enhanced production of IFN-gamma may modulate HSV replication and B7 expression on monocytic cells of HSV-infected individuals. In contrast to seronegative controls, IFN-gamma failed to enhance B7 expression on monocytic cells of HSV-infected individuals. In addition, monocytic cells from HSV-2-infected individuals with recurrent disease supported greater HSV replication than did those of HSV-infected asymptomatic individuals or seronegative controls. Furthermore, addition of IFN-gamma resulted in enhanced HSV replication in monocytic cells of HSV-infected individuals with recurrent disease, in contrast to the inhibition observed in HSV-seropositive asymptomatic individuals and seronegative controls. Taken together, our results suggest that dysregulated production of IFN-gamma at different disease stages and the impaired ability of monocytic cells to respond to IFN-gamma may play a role in the pathogenesis of recurrent genital herpes disease. | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12823283 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12823283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12823283 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12823283 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12823283 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:12823283 | pubmed:author | pubmed-author:KumarAA | lld:pubmed |
| pubmed-article:12823283 | pubmed:author | pubmed-author:SinghRR | lld:pubmed |
| pubmed-article:12823283 | pubmed:author | pubmed-author:RubenMM | lld:pubmed |
| pubmed-article:12823283 | pubmed:author | pubmed-author:GiuliviAA | lld:pubmed |
| pubmed-article:12823283 | pubmed:author | pubmed-author:Diaz-MitomaFF | lld:pubmed |
| pubmed-article:12823283 | pubmed:author | pubmed-author:CreeryW DWD | lld:pubmed |
| pubmed-article:12823283 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12823283 | pubmed:volume | 133 | lld:pubmed |
| pubmed-article:12823283 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12823283 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12823283 | pubmed:pagination | 97-107 | lld:pubmed |
| pubmed-article:12823283 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
| pubmed-article:12823283 | pubmed:meshHeading | pubmed-meshheading:12823283... | lld:pubmed |
