| pubmed-article:12817471 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12817471 | lifeskim:mentions | umls-concept:C0033607 | lld:lifeskim |
| pubmed-article:12817471 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:12817471 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:12817471 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:12817471 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12817471 | pubmed:dateCreated | 2003-6-23 | lld:pubmed |
| pubmed-article:12817471 | pubmed:abstractText | Bikunin is a Kunitz-type protease inhibitor predominantly found in human amniotic fluid. In cancers, administration of bikunin may block tumor cell invasion by a direct inhibition of tumor cell-associated plasmin activity as well as by inhibiting urokinase-type plasminogen activator (uPA) expression at the gene and protein levels, possibly through suppression of CD44 dimerization and/or the MAP kinase signaling cascade. Treatment of cancer patients with bikunin may be beneficial in the adjuvant setting to delay the onset of metastasis development and/or in combination with cytotoxic agents to improve treatment efficacy in patients with advanced ovarian cancer. | lld:pubmed |
| pubmed-article:12817471 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12817471 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12817471 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12817471 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12817471 | pubmed:month | May | lld:pubmed |
| pubmed-article:12817471 | pubmed:issn | 1431-6730 | lld:pubmed |
| pubmed-article:12817471 | pubmed:author | pubmed-author:KobayashiHiro... | lld:pubmed |
| pubmed-article:12817471 | pubmed:author | pubmed-author:SuzukiMikaM | lld:pubmed |
| pubmed-article:12817471 | pubmed:author | pubmed-author:TeraoToshihik... | lld:pubmed |
| pubmed-article:12817471 | pubmed:author | pubmed-author:HirashimaYasu... | lld:pubmed |
| pubmed-article:12817471 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12817471 | pubmed:volume | 384 | lld:pubmed |
| pubmed-article:12817471 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12817471 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12817471 | pubmed:pagination | 749-54 | lld:pubmed |
| pubmed-article:12817471 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12817471 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12817471 | pubmed:articleTitle | The protease inhibitor bikunin, a novel anti-metastatic agent. | lld:pubmed |
| pubmed-article:12817471 | pubmed:affiliation | Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka, 431-3192, Japan. | lld:pubmed |
| pubmed-article:12817471 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12817471 | pubmed:publicationType | Review | lld:pubmed |
| entrez-gene:259 | entrezgene:pubmed | pubmed-article:12817471 | lld:entrezgene |
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