| pubmed-article:12807736 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12807736 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12807736 | lifeskim:mentions | umls-concept:C0850572 | lld:lifeskim |
| pubmed-article:12807736 | lifeskim:mentions | umls-concept:C0041582 | lld:lifeskim |
| pubmed-article:12807736 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:12807736 | lifeskim:mentions | umls-concept:C0239059 | lld:lifeskim |
| pubmed-article:12807736 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:12807736 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:12807736 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12807736 | pubmed:dateCreated | 2003-8-6 | lld:pubmed |
| pubmed-article:12807736 | pubmed:abstractText | Both chronic ulcerative colitis and smoking are associated with colorectal cancer in humans. In the present study, we investigated the effects of cigarette smoke (CS) exposure on inflammation-associated tumorigenesis in the mouse colon. Male balb/c mice were allocated into six groups: control, CS (2%), CS (4%), colitis, colitis + CS (2%) and colitis + CS (4%). They were given water or 3% dextran sulfate sodium (DSS) in drinking water for 7 days to induce colitis, with or without 1 h daily exposure to 2 or 4% CS. They were then allowed to drink water for 14 days. The cycle of 7 day DSS +/- CS/14 day H2O treatments were repeated twice. Mice were killed immediately or 1 month after the three cycles of treatments. Results indicated colonic adenoma was only found in the colitis group (one out of 11), Colitis + CS (2%) group (seven out of 12) and colitis + CS (4%) group (four out of five) 1 month after three cycles of DSS and/or CS treatment. CS exposure dose-dependently increased adenoma formation in mice with inflamed mucosa. CS exposure plus colitis was strongly associated with a high incidence of dysplasia (P < 0.01) and adenocarcinoma formation (P < 0.01) compared with induction of colitis alone. Colitis induced cell proliferation and apoptosis in colonic tissues. Cigarette smoking significantly attenuated the apoptotic effect by DSS probably via the induction of anti-apoptotic protein bcl-2. The ratio of apoptosis over proliferation was also significantly lower in the colitis + CS groups. Vascular endothelial growth factor and angiogenesis in the colon were also increased by cigarette smoking in animals with colitis. In conclusion, CS promotes inflammation-associated adenoma/adenocarcinoma formation in the mouse colon in a dose-dependent manner. This tumor development is associated with the inhibition of cellular apoptosis and supported by increased angiogenesis. | lld:pubmed |
| pubmed-article:12807736 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12807736 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12807736 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12807736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12807736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12807736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12807736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12807736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12807736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12807736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12807736 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12807736 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12807736 | pubmed:issn | 0143-3334 | lld:pubmed |
| pubmed-article:12807736 | pubmed:author | pubmed-author:ShinVivian... | lld:pubmed |
| pubmed-article:12807736 | pubmed:author | pubmed-author:LiuEdgar S... | lld:pubmed |
| pubmed-article:12807736 | pubmed:author | pubmed-author:ChoChi-HinCH | lld:pubmed |
| pubmed-article:12807736 | pubmed:author | pubmed-author:YuenSiu-TsanS... | lld:pubmed |
| pubmed-article:12807736 | pubmed:author | pubmed-author:WongBenjamin... | lld:pubmed |
| pubmed-article:12807736 | pubmed:author | pubmed-author:YeYi-NiYN | lld:pubmed |
| pubmed-article:12807736 | pubmed:author | pubmed-author:LeungSuet-YiS... | lld:pubmed |
| pubmed-article:12807736 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12807736 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:12807736 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12807736 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12807736 | pubmed:pagination | 1407-13 | lld:pubmed |
| pubmed-article:12807736 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12807736 | pubmed:meshHeading | pubmed-meshheading:12807736... | lld:pubmed |
| pubmed-article:12807736 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12807736 | pubmed:articleTitle | Cigarette smoke exposure increases ulcerative colitis-associated colonic adenoma formation in mice. | lld:pubmed |
| pubmed-article:12807736 | pubmed:affiliation | Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China. | lld:pubmed |
| pubmed-article:12807736 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12807736 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12807736 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12807736 | lld:pubmed |
