| pubmed-article:12799619 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12799619 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:12799619 | lifeskim:mentions | umls-concept:C0007407 | lld:lifeskim |
| pubmed-article:12799619 | lifeskim:mentions | umls-concept:C0162783 | lld:lifeskim |
| pubmed-article:12799619 | lifeskim:mentions | umls-concept:C0036341 | lld:lifeskim |
| pubmed-article:12799619 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:12799619 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12799619 | pubmed:dateCreated | 2003-7-23 | lld:pubmed |
| pubmed-article:12799619 | pubmed:abstractText | Human prefrontal cortical neurons express catechol O-methyltransferase (COMT), an enzyme that inactivates the neurotransmitter dopamine. A functional polymorphism of COMT, Val(108/158) Met, affects prefrontal function, and the high-activity Val allele has been reported to be a genetic risk factor for schizophrenia. We used in situ hybridization histochemistry to measure mRNA levels of COMT in the dorsolateral prefrontal cortex (DLPFC) of patients with schizophrenia (N=14) and of normal controls (N=15). While the groups did not differ in terms of mean level of COMT mRNA, there was a significantly different laminar pattern of COMT mRNA expression in pyramidal neurons (F=2.68, df=4,108, P <0.04); patients with schizophrenia had relatively lower levels in the superficial (II/III) layers and higher levels in the intermediate/deep (IV/V) layers (P&<0.01), while in controls, the expression was homogeneous across layers. Neither the mean level nor the laminar distribution of COMT mRNA was related to the Val(108/158) Met genotype, suggesting that the feedback regulation of mRNA level is not a compensation for the functional effect of the COMT polymorphism. The disease-related laminar difference of COMT expression may be involved in dysregulation of dopamine signaling circuits in the DLPFC of patients with schizophrenia. | lld:pubmed |
| pubmed-article:12799619 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12799619 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12799619 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12799619 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12799619 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12799619 | pubmed:issn | 0893-133X | lld:pubmed |
| pubmed-article:12799619 | pubmed:author | pubmed-author:HydeThomas... | lld:pubmed |
| pubmed-article:12799619 | pubmed:author | pubmed-author:WeinbergerDan... | lld:pubmed |
| pubmed-article:12799619 | pubmed:author | pubmed-author:HermanMary... | lld:pubmed |
| pubmed-article:12799619 | pubmed:author | pubmed-author:ChenJingshanJ | lld:pubmed |
| pubmed-article:12799619 | pubmed:author | pubmed-author:KleinmanJoel... | lld:pubmed |
| pubmed-article:12799619 | pubmed:author | pubmed-author:MatsumotoMits... | lld:pubmed |
| pubmed-article:12799619 | pubmed:author | pubmed-author:KolachanaBhas... | lld:pubmed |
| pubmed-article:12799619 | pubmed:author | pubmed-author:WeickertCynth... | lld:pubmed |
| pubmed-article:12799619 | pubmed:author | pubmed-author:BeltaifaSenda... | lld:pubmed |
| pubmed-article:12799619 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12799619 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:12799619 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12799619 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12799619 | pubmed:pagination | 1521-30 | lld:pubmed |
| pubmed-article:12799619 | pubmed:dateRevised | 2011-5-18 | lld:pubmed |
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| pubmed-article:12799619 | pubmed:meshHeading | pubmed-meshheading:12799619... | lld:pubmed |
| pubmed-article:12799619 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12799619 | pubmed:articleTitle | Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia. | lld:pubmed |
| pubmed-article:12799619 | pubmed:affiliation | Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA. matsum_m@yamanouchi.co.jp | lld:pubmed |
| pubmed-article:12799619 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12799619 | pubmed:publicationType | Comparative Study | lld:pubmed |
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