| pubmed-article:12793460 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12793460 | lifeskim:mentions | umls-concept:C0032081 | lld:lifeskim |
| pubmed-article:12793460 | lifeskim:mentions | umls-concept:C0001044 | lld:lifeskim |
| pubmed-article:12793460 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:12793460 | lifeskim:mentions | umls-concept:C0806140 | lld:lifeskim |
| pubmed-article:12793460 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:12793460 | lifeskim:mentions | umls-concept:C1510438 | lld:lifeskim |
| pubmed-article:12793460 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12793460 | pubmed:dateCreated | 2003-6-9 | lld:pubmed |
| pubmed-article:12793460 | pubmed:abstractText | A fluorometric assay for acetylcholinesterase inhibitory activity was developed in a flow system using the fluorogenic substrate 7-acetoxy-1-methyl quinolinium iodide which is hydrolysed to the highly fluorescent 7-hydroxy-1-methyl quinolinium iodide. The detection limit of galanthamine is 0.5 microM, which is about 20 times more sensitive than in the colorimetric flow assay. In the presence of 30% methanol or of 5% acetonitrile, about 70% of the enzyme activity could still be detected. Various plant extracts have been screened using the described system including bulbs of Galanthus nivalis, Eucharis amazonica (E. x grandiflora), Crinum powelli and Nerine bowdenii (all members of the Amaryllidaceae), which showed strong AchE inhibitory activity. | lld:pubmed |
| pubmed-article:12793460 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12793460 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12793460 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12793460 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12793460 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12793460 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12793460 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12793460 | pubmed:issn | 0958-0344 | lld:pubmed |
| pubmed-article:12793460 | pubmed:author | pubmed-author:VerpoorteRobe... | lld:pubmed |
| pubmed-article:12793460 | pubmed:author | pubmed-author:LuijendijkTeu... | lld:pubmed |
| pubmed-article:12793460 | pubmed:author | pubmed-author:RheeIn... | lld:pubmed |
| pubmed-article:12793460 | pubmed:author | pubmed-author:AppelsNatalie... | lld:pubmed |
| pubmed-article:12793460 | pubmed:author | pubmed-author:IrthHubertusH | lld:pubmed |
| pubmed-article:12793460 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12793460 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:12793460 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12793460 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12793460 | pubmed:pagination | 145-9 | lld:pubmed |
| pubmed-article:12793460 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12793460 | pubmed:meshHeading | pubmed-meshheading:12793460... | lld:pubmed |
| pubmed-article:12793460 | pubmed:meshHeading | pubmed-meshheading:12793460... | lld:pubmed |
| pubmed-article:12793460 | pubmed:meshHeading | pubmed-meshheading:12793460... | lld:pubmed |
| pubmed-article:12793460 | pubmed:meshHeading | pubmed-meshheading:12793460... | lld:pubmed |
| pubmed-article:12793460 | pubmed:meshHeading | pubmed-meshheading:12793460... | lld:pubmed |
| pubmed-article:12793460 | pubmed:meshHeading | pubmed-meshheading:12793460... | lld:pubmed |
| pubmed-article:12793460 | pubmed:meshHeading | pubmed-meshheading:12793460... | lld:pubmed |
| pubmed-article:12793460 | pubmed:articleTitle | Determining acetylcholinesterase inhibitory activity in plant extracts using a fluorimetric flow assay. | lld:pubmed |
| pubmed-article:12793460 | pubmed:affiliation | Division of Pharmacognosy, Leiden/Amsterdam Centre for Drug Research, Gorlaeus Laboratories, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands. | lld:pubmed |
| pubmed-article:12793460 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12793460 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12793460 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12793460 | lld:pubmed |
