| pubmed-article:1278183 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1278183 | lifeskim:mentions | umls-concept:C0679729 | lld:lifeskim |
| pubmed-article:1278183 | lifeskim:mentions | umls-concept:C0814999 | lld:lifeskim |
| pubmed-article:1278183 | lifeskim:mentions | umls-concept:C0009630 | lld:lifeskim |
| pubmed-article:1278183 | lifeskim:mentions | umls-concept:C0034794 | lld:lifeskim |
| pubmed-article:1278183 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:1278183 | lifeskim:mentions | umls-concept:C0439237 | lld:lifeskim |
| pubmed-article:1278183 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1278183 | pubmed:dateCreated | 1976-9-2 | lld:pubmed |
| pubmed-article:1278183 | pubmed:abstractText | The mode of binding of 125I-labelled concanavalin A and succinyl-concanavalin A to rat thymocytes at 4 degrees C was investigated. Simultaneously, the free binding sites of the cell-bound lectin molecules were quantified by horseradish peroxidase binding. Concanavalin A showed cooperative binding while succinyl-concanavalin A did not. The number of molecules of concanavalin A bound to the cell surface when it was saturated was twice the number of molecules of succinyl-concanavalin A. We interpret these results as showing that the binding of native concanavalin A to thymocytes at 4 degrees C brings about a cooperative modification of the membrane which leads to appearance of new receptors. Divalent succinyl-concanavalin A has no such effect. Horseradish peroxidase binding to cell-bound lectin was shown to be related to the immobilization of membrane receptors; the more they are immobilized, the more receptor-associated lectin can bind horseradish peroxidase. This allowed us to establish that post-binding events, which we called micro-redistribution, occurred at 4 degrees C when either concanavalin A or succinyl-concanavalin A binds to cells. A cooperative restriction of the micromobility of cell receptors is produced by increasing concentrations of concanavalin A. Succinyl-concanavalin A does not restrict cell receptor mobility at any concentration tested. The results are discussed in terms of cell stimulation and cell agglutination. | lld:pubmed |
| pubmed-article:1278183 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1278183 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1278183 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1278183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1278183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1278183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1278183 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1278183 | pubmed:month | May | lld:pubmed |
| pubmed-article:1278183 | pubmed:issn | 0014-2956 | lld:pubmed |
| pubmed-article:1278183 | pubmed:author | pubmed-author:AvrameasSS | lld:pubmed |
| pubmed-article:1278183 | pubmed:author | pubmed-author:BornensMM | lld:pubmed |
| pubmed-article:1278183 | pubmed:author | pubmed-author:KarsentiEE | lld:pubmed |
| pubmed-article:1278183 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1278183 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:1278183 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:1278183 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1278183 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1278183 | pubmed:pagination | 61-9 | lld:pubmed |
| pubmed-article:1278183 | pubmed:dateRevised | 2007-7-23 | lld:pubmed |
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| pubmed-article:1278183 | pubmed:meshHeading | pubmed-meshheading:1278183-... | lld:pubmed |
| pubmed-article:1278183 | pubmed:year | 1976 | lld:pubmed |
| pubmed-article:1278183 | pubmed:articleTitle | Cooperative binding of concanavalin A to thymocytes at 4 degrees C and micro-redistribution of concanavalin A receptors. | lld:pubmed |
| pubmed-article:1278183 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1278183 | pubmed:publicationType | In Vitro | lld:pubmed |
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