| pubmed-article:12780684 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12780684 | lifeskim:mentions | umls-concept:C0030664 | lld:lifeskim |
| pubmed-article:12780684 | lifeskim:mentions | umls-concept:C0085508 | lld:lifeskim |
| pubmed-article:12780684 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12780684 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:12780684 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:12780684 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:12780684 | lifeskim:mentions | umls-concept:C1522538 | lld:lifeskim |
| pubmed-article:12780684 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12780684 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:12780684 | lifeskim:mentions | umls-concept:C2698594 | lld:lifeskim |
| pubmed-article:12780684 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12780684 | pubmed:dateCreated | 2003-6-3 | lld:pubmed |
| pubmed-article:12780684 | pubmed:abstractText | Helicobacter pylori induces symptomatic chronic gastritis in a subpopulation of infected individuals. The mechanism(s) determining the development and severity of pathology leading to symptoms are not fully understood. In a mouse model of H. pylori infection we analysed the influence of immunoregulatory CD4+CD25+ T cells on H. pylori colonization and gastritis. Athymic C57BL/6 nu/nu mice were reconstituted with (a) lymph node (LN) cells (b) LN cells depleted of CD25+ T cells (CD25(-) LN) or (c) not reconstituted at all. Mice were then infected orally with 3 x 10(8)H. pylori SS1 bacteria. At 2 and 6 weeks after the inoculation there was a significant (P < 0.001) reduction in H. pylori colonization in athymic mice transferred with CD25(-) LN cells compared to mice transferred with LN cells. Colonization was still reduced at 12 weeks after inoculation. Mice transferred with CD25(-) LN cells showed an earlier onset and increased severity of gastritis as compared to mice receiving LN cells. Splenic cells isolated from mice receiving CD25(-) LN cells produced the highest level of IFN-gamma on stimulation with H. pylori antigens in vitro, had a higher H. pylori-specific DTH response and increased infiltration of CD4+ T cells and macrophages in the gastric mucosa. Athymic mice not transferred with T cells had persistent high H. pylori colonization and displayed a normal gastric epithelium without inflammatory cells. In conclusion, CD4+CD25+ cells reduce immunopathology in H. pylori infection, possibly by reducing the activation of IFN-gamma producing CD4+ T cells, even at the expense of a higher H. pylori load in the gastric mucosa. | lld:pubmed |
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| pubmed-article:12780684 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12780684 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12780684 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12780684 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12780684 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12780684 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12780684 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:12780684 | pubmed:author | pubmed-author:HolmgrenJJ | lld:pubmed |
| pubmed-article:12780684 | pubmed:author | pubmed-author:RaghavanSS | lld:pubmed |
| pubmed-article:12780684 | pubmed:author | pubmed-author:FredrikssonMM | lld:pubmed |
| pubmed-article:12780684 | pubmed:author | pubmed-author:Suri-PayerEE | lld:pubmed |
| pubmed-article:12780684 | pubmed:author | pubmed-author:SvennerholmA-... | lld:pubmed |
| pubmed-article:12780684 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12780684 | pubmed:volume | 132 | lld:pubmed |
| pubmed-article:12780684 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12780684 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12780684 | pubmed:pagination | 393-400 | lld:pubmed |
| pubmed-article:12780684 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12780684 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12780684 | pubmed:articleTitle | Absence of CD4+CD25+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice. | lld:pubmed |
| pubmed-article:12780684 | pubmed:affiliation | Department of Medical Microbiology and Immunology, Göteborg University, Göteborg, Sweden. sukanya.raghavan@microbio.gu.se | lld:pubmed |
| pubmed-article:12780684 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12780684 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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