| pubmed-article:12771433 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12771433 | lifeskim:mentions | umls-concept:C0029341 | lld:lifeskim |
| pubmed-article:12771433 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:12771433 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12771433 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12771433 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12771433 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:12771433 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12771433 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12771433 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:12771433 | pubmed:issue | Pt 6 | lld:pubmed |
| pubmed-article:12771433 | pubmed:dateCreated | 2003-5-28 | lld:pubmed |
| pubmed-article:12771433 | pubmed:abstractText | The SAM-P1 strain of senescence-accelerated model mice shows an impaired T helper type 1 (Th1) immune response upon infection with influenza virus, which results in high susceptibility to the virus. Treatment of spleen cells from SAM-P1 mice with an immunostimulatory oligodeoxynucleotide containing a cytidine-guanosine motif (CpG ODN) in vitro increased the ratio of the titre of IFN-gamma to that of IL-4. Administration of CpG ODN to SAM-P1 mice generated satisfactory virus-specific cytotoxic T-lymphocyte responses and natural killer cell activation and the virus-specific immunoglobulin (Ig) isotype switched from IgG1 to IgG2a. Virus growth in the lungs of CpG ODN-treated SAM-P1 mice was cleared quickly and mice survived the lethal influenza virus infection. It could be inferred that a possible mechanism of CpG ODN for normalization of senescence-associated dysregulation of the Th1/Th2 balance involves the upregulated expression of CD154 and CD40 molecules on immune-competent cells. These results suggest that CpG ODN could contribute to the development of a protective strategy against infectious diseases, especially among immunocompromised elderly persons, by stimulating Th1 immune responses. | lld:pubmed |
| pubmed-article:12771433 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12771433 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12771433 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12771433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12771433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12771433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12771433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12771433 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12771433 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12771433 | pubmed:issn | 0022-1317 | lld:pubmed |
| pubmed-article:12771433 | pubmed:author | pubmed-author:DongLiL | lld:pubmed |
| pubmed-article:12771433 | pubmed:author | pubmed-author:KimuraYoshino... | lld:pubmed |
| pubmed-article:12771433 | pubmed:author | pubmed-author:MoriIsamuI | lld:pubmed |
| pubmed-article:12771433 | pubmed:author | pubmed-author:LiuBeixingB | lld:pubmed |
| pubmed-article:12771433 | pubmed:author | pubmed-author:HossainMd... | lld:pubmed |
| pubmed-article:12771433 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12771433 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:12771433 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12771433 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12771433 | pubmed:pagination | 1623-8 | lld:pubmed |
| pubmed-article:12771433 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12771433 | pubmed:meshHeading | pubmed-meshheading:12771433... | lld:pubmed |
| pubmed-article:12771433 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12771433 | pubmed:articleTitle | An immunostimulatory oligodeoxynucleotide containing a cytidine-guanosine motif protects senescence-accelerated mice from lethal influenza virus by augmenting the T helper type 1 response. | lld:pubmed |
| pubmed-article:12771433 | pubmed:affiliation | Department of Microbiology, Fukui Medical University School of Medicine, Shimoaizuki 23-3, Matsuoka-cho, Yoshida-gun, Japan. | lld:pubmed |
| pubmed-article:12771433 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12771433 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12771433 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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