| pubmed-article:12767395 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12767395 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:12767395 | lifeskim:mentions | umls-concept:C0205174 | lld:lifeskim |
| pubmed-article:12767395 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:12767395 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:12767395 | lifeskim:mentions | umls-concept:C0205088 | lld:lifeskim |
| pubmed-article:12767395 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12767395 | pubmed:dateCreated | 2003-5-27 | lld:pubmed |
| pubmed-article:12767395 | pubmed:abstractText | A novel procedure for the high-yield preparation of Re-188 radiopharmaceuticals containing a terminal Re identical with N multiple bond is described. This method involves the reaction of [(188)Re][ReO(4)](-) with N-methyl S-methyl dithiocarbazate (DTCZ), as donor of nitrido nitrogen atoms, sodium oxalate and SnCl(2) to afford a mixture of two intermediate compounds. When this mixture is reacted with the sodium salt of a dithiocarbamate ligand (L) of the type Na[R(2)N-C(=S)S] (R = CH(3), CH(3)CH(2), CH(3)CH(2)CH(2)), the formation of the bis-substituted, neutral complexes [(188)Re][Re(N)(L)(2)] is easily obtained in high yield (> 95%). The complexes [(188)Re][Re(N)(L)(2)] were characterized by chromatographic methods, and by comparison with the corresponding complexes prepared at macroscopic level starting from a non-radioactive rhenium precursor. Biodistribution studies were carried out in rats. Results showed that the complexes [(188)Re][Re(N)(L)(2)] exhibited the same biological behavior of the analogous Tc-99m complexes reported previously. The easy application of the new synthetic procedure indicates that it could be conveniently employed for preparing a large class of new Re-188 complexes having potential utilization in nuclear medicine as therapeutic agents. | lld:pubmed |
| pubmed-article:12767395 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12767395 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767395 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12767395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767395 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12767395 | pubmed:month | May | lld:pubmed |
| pubmed-article:12767395 | pubmed:issn | 0969-8051 | lld:pubmed |
| pubmed-article:12767395 | pubmed:author | pubmed-author:BolzatiCristi... | lld:pubmed |
| pubmed-article:12767395 | pubmed:author | pubmed-author:BoschiAlessan... | lld:pubmed |
| pubmed-article:12767395 | pubmed:author | pubmed-author:UccelliLiciaL | lld:pubmed |
| pubmed-article:12767395 | pubmed:author | pubmed-author:DuattiAdriano... | lld:pubmed |
| pubmed-article:12767395 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12767395 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:12767395 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12767395 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12767395 | pubmed:pagination | 381-7 | lld:pubmed |
| pubmed-article:12767395 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:12767395 | pubmed:meshHeading | pubmed-meshheading:12767395... | lld:pubmed |
| pubmed-article:12767395 | pubmed:meshHeading | pubmed-meshheading:12767395... | lld:pubmed |
| pubmed-article:12767395 | pubmed:meshHeading | pubmed-meshheading:12767395... | lld:pubmed |
| pubmed-article:12767395 | pubmed:meshHeading | pubmed-meshheading:12767395... | lld:pubmed |
| pubmed-article:12767395 | pubmed:meshHeading | pubmed-meshheading:12767395... | lld:pubmed |
| pubmed-article:12767395 | pubmed:meshHeading | pubmed-meshheading:12767395... | lld:pubmed |
| pubmed-article:12767395 | pubmed:meshHeading | pubmed-meshheading:12767395... | lld:pubmed |
| pubmed-article:12767395 | pubmed:meshHeading | pubmed-meshheading:12767395... | lld:pubmed |
| pubmed-article:12767395 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12767395 | pubmed:articleTitle | High-yield synthesis of the terminal 188Re triple bond N multiple bond from generator-produced [188ReO4](-). | lld:pubmed |
| pubmed-article:12767395 | pubmed:affiliation | Laboratory of Nuclear Medicine, Department of Clinical & Experimental Medicine, University of Ferrara, Via L. Borsari, 46, 44100 Ferrara, Italy. | lld:pubmed |
| pubmed-article:12767395 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12767395 | lld:pubmed |
