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pubmed-article:12762988pubmed:abstractTextSignificant artifacts arise in T(1rho)-weighted imaging when nutation angles suffer small deviations from their expected values. These artifacts vary with spin-locking time and amplitude, severely limiting attempts to perform quantitative imaging or measurement of T(1rho) relaxation times. A theoretical model explaining the origin of these artifacts is presented in the context of a T(1rho)-prepared fast spin-echo imaging sequence. Experimentally obtained artifacts are compared to those predicted by theory and related to B(1) inhomogeneity. Finally, a "self-compensating" spin-locking preparatory pulse cluster is presented, in which the second half of the spin-locking pulse is phase-shifted by 180 degrees. Use of this pulse sequence maintains relatively uniform signal intensity despite large variations in flip angle, greatly reducing artifacts in T(1rho)-weighted imaging.lld:pubmed
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pubmed-article:12762988pubmed:authorpubmed-author:BorthakurArij...lld:pubmed
pubmed-article:12762988pubmed:authorpubmed-author:ReddyRavinder...lld:pubmed
pubmed-article:12762988pubmed:authorpubmed-author:LeighJohn SJSlld:pubmed
pubmed-article:12762988pubmed:authorpubmed-author:CharagundlaSr...lld:pubmed
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pubmed-article:12762988pubmed:pagination113-21lld:pubmed
pubmed-article:12762988pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:12762988pubmed:year2003lld:pubmed
pubmed-article:12762988pubmed:articleTitleArtifacts in T(1rho)-weighted imaging: correction with a self-compensating spin-locking pulse.lld:pubmed
pubmed-article:12762988pubmed:affiliationB1 Stellar-Chance Laboratories, MMRRCC, Department of Radiology, University of Pennsylvania, 422 Curie Boulevard, Philadelphia, PA 19104-6100, USA. Sridhar@mail.mmrrcc.upenn.edulld:pubmed
pubmed-article:12762988pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12762988pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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