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pubmed-article:12759805pubmed:abstractTextImpaired auditory gating is common in schizophrenic patients. Evidence suggests that this deficit is related to a reduced number of alpha(7) nicotinic receptors and therefore treatment with alpha(7) nicotinic agonists may improve this condition. 3-(2,4)-Dimethoxybenzylidine anabaseine (DMXB; also known as GTS-21) is such an agonist and has shown efficacy in mice both orally and intraperitoneally.lld:pubmed
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pubmed-article:12759805pubmed:articleTitleDMXB, an alpha7 nicotinic agonist, normalizes auditory gating in isolation-reared rats.lld:pubmed
pubmed-article:12759805pubmed:affiliationDepartment of Psychiatry C268-71, University of Colorado Health Sciences Center, 4200 East 9th Avenue,Denver, CO 80262, USA.lld:pubmed
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