| pubmed-article:12665596 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12665596 | lifeskim:mentions | umls-concept:C0166886 | lld:lifeskim |
| pubmed-article:12665596 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:12665596 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:12665596 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:12665596 | lifeskim:mentions | umls-concept:C0597767 | lld:lifeskim |
| pubmed-article:12665596 | lifeskim:mentions | umls-concept:C0443254 | lld:lifeskim |
| pubmed-article:12665596 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:12665596 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:12665596 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:12665596 | lifeskim:mentions | umls-concept:C0719053 | lld:lifeskim |
| pubmed-article:12665596 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12665596 | pubmed:dateCreated | 2003-3-31 | lld:pubmed |
| pubmed-article:12665596 | pubmed:abstractText | CTF7/ECO1 is an essential yeast gene required for the establishment of sister chromatid cohesion. The findings that CTF7/ECO1, POL30 (PCNA), and CHL12/CTF18 (a replication factor C [RFC] homolog) genetically interact provided the first evidence that the processes of cohesion establishment and DNA replication are intimately coupled-a link now confirmed by other studies. To date, however, it is unknown how Ctf7p/Eco1p function is coupled to DNA replication or whether Ctf7p/Eco1p physically associates with any components of the DNA replication machinery. Here, we report that Ctf7p/Eco1p associates with proteins that perform partially redundant functions in DNA replication. Chl12p/Ctf18p combines with Rfc2p to Rfc5p to form one of three independent RFC complexes. By chromatographic methods, Ctf7p/Eco1p was found to associate with Chl12/Ctf18p and with Rfc2p, Rfc3p, Rfc4p, and Rfc5p. The association between Ctf7p/Eco1p and this RFC complex is biologically relevant in that (i) Ctf7p/Eco1p cosediments with Chl12p/Ctf18p in vivo and (ii) rfc5-1 mutant cells exhibit precocious sister separation. Previous studies revealed that Rfc1p or Rad24p associates with Rfc2p to Rfc5p to form two other RFC complexes independent of Ctf18p-RFC complexes. These Rfc1p-RFC and Rad24p-RFC complexes function in DNA replication or repair and DNA damage checkpoint pathways. Importantly, Ctf7p/Eco1p also associates with Rfc1p and Rad24p, suggesting that these RFC complexes also play critical roles in cohesion establishment. The associations between Ctf7p/Eco1p and RFC subunits provide novel evidence regarding the physical linkage between cohesion establishment and DNA replication. Furthermore, the association of Ctf7p/Eco1p with each of three RFC complexes supplies new insights into the functional redundancy of RFC complexes in cohesion establishment. | lld:pubmed |
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| pubmed-article:12665596 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12665596 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12665596 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12665596 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12665596 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12665596 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12665596 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12665596 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:12665596 | pubmed:author | pubmed-author:KennaMargaret... | lld:pubmed |
| pubmed-article:12665596 | pubmed:author | pubmed-author:SkibbensRober... | lld:pubmed |
| pubmed-article:12665596 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12665596 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:12665596 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12665596 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12665596 | pubmed:pagination | 2999-3007 | lld:pubmed |
| pubmed-article:12665596 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12665596 | pubmed:meshHeading | pubmed-meshheading:12665596... | lld:pubmed |
