| pubmed-article:12651903 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12651903 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12651903 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:12651903 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:12651903 | lifeskim:mentions | umls-concept:C0002630 | lld:lifeskim |
| pubmed-article:12651903 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12651903 | lifeskim:mentions | umls-concept:C0022864 | lld:lifeskim |
| pubmed-article:12651903 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:12651903 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12651903 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12651903 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:12651903 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:12651903 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:12651903 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12651903 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12651903 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12651903 | pubmed:dateCreated | 2003-3-24 | lld:pubmed |
| pubmed-article:12651903 | pubmed:abstractText | Human labour is associated with persistently increased nuclear factor kappa B (NF-kB) activity in amnion. In this study we have shown that this involves only the p65 and p50 NF-kB subunits and is associated with an increase in the expression of p65 (P < 0.05), and of the NF-kB binding proteins IkBa, IkBb-1 and IkBb-2 (P < 0.05). Interleukin-1b stimulation leads to rapid degradation and resynthesis of IkBa within 2 h, and a decrease in IkBb-1 without a return to full expression by 2 h, but has little effect upon IkBb-2. IkBb-2 was found in both the cytosolic and nuclear protein fractions. These findings demonstrate that persistently increased NF-kB activity in amnion occurs despite increased expression of the inhibitory IkBa protein and is not mediated by persistant I-kappa kinase activity or inhibition of IkBa synthesis. The increased expression and nuclear localization of IkBb-2 suggests that its function may be to protect NF-kB from inactivation by IkBa and to maintain NF-kB-mediated gene transcription. | lld:pubmed |
| pubmed-article:12651903 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12651903 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12651903 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12651903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12651903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12651903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12651903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12651903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12651903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12651903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12651903 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12651903 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12651903 | pubmed:issn | 1360-9947 | lld:pubmed |
| pubmed-article:12651903 | pubmed:author | pubmed-author:LeeYooniY | lld:pubmed |
| pubmed-article:12651903 | pubmed:author | pubmed-author:AllportVictor... | lld:pubmed |
| pubmed-article:12651903 | pubmed:author | pubmed-author:SykesAnnaA | lld:pubmed |
| pubmed-article:12651903 | pubmed:author | pubmed-author:LindstromTams... | lld:pubmed |
| pubmed-article:12651903 | pubmed:author | pubmed-author:SlaterDonnaD | lld:pubmed |
| pubmed-article:12651903 | pubmed:author | pubmed-author:BennettPhilli... | lld:pubmed |
| pubmed-article:12651903 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12651903 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:12651903 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12651903 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12651903 | pubmed:pagination | 213-8 | lld:pubmed |
| pubmed-article:12651903 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12651903 | pubmed:meshHeading | pubmed-meshheading:12651903... | lld:pubmed |
| pubmed-article:12651903 | pubmed:meshHeading | pubmed-meshheading:12651903... | lld:pubmed |
| pubmed-article:12651903 | pubmed:meshHeading | pubmed-meshheading:12651903... | lld:pubmed |
| pubmed-article:12651903 | pubmed:meshHeading | pubmed-meshheading:12651903... | lld:pubmed |
| pubmed-article:12651903 | pubmed:meshHeading | pubmed-meshheading:12651903... | lld:pubmed |
| pubmed-article:12651903 | pubmed:meshHeading | pubmed-meshheading:12651903... | lld:pubmed |
| pubmed-article:12651903 | pubmed:meshHeading | pubmed-meshheading:12651903... | lld:pubmed |
| pubmed-article:12651903 | pubmed:meshHeading | pubmed-meshheading:12651903... | lld:pubmed |
| pubmed-article:12651903 | pubmed:meshHeading | pubmed-meshheading:12651903... | lld:pubmed |
| pubmed-article:12651903 | pubmed:meshHeading | pubmed-meshheading:12651903... | lld:pubmed |
| pubmed-article:12651903 | pubmed:meshHeading | pubmed-meshheading:12651903... | lld:pubmed |
| pubmed-article:12651903 | pubmed:meshHeading | pubmed-meshheading:12651903... | lld:pubmed |
| pubmed-article:12651903 | pubmed:meshHeading | pubmed-meshheading:12651903... | lld:pubmed |
| pubmed-article:12651903 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12651903 | pubmed:articleTitle | The effects of labour and of interleukin 1 beta upon the expression of nuclear factor kappa B related proteins in human amnion. | lld:pubmed |
| pubmed-article:12651903 | pubmed:affiliation | Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Hammersmith Hospital Campus, DuCane Road, London W12 0NN. | lld:pubmed |
| pubmed-article:12651903 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12651903 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:4792 | entrezgene:pubmed | pubmed-article:12651903 | lld:entrezgene |
| entrez-gene:4793 | entrezgene:pubmed | pubmed-article:12651903 | lld:entrezgene |
| entrez-gene:5970 | entrezgene:pubmed | pubmed-article:12651903 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12651903 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12651903 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12651903 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12651903 | lld:pubmed |
